合体滋养细胞微绒毛膜在子痫前期发病中作用的研究-妇产科学专业论文.docxVIP

第三军医大学硕士学位论文 第三军医大学硕士学位论文 万方数据 万方数据 ml Milliliter 毫升 fl Femtoliter 飞升 nm Nanometer 纳米 d Day 天 h Hour 小时 min Minute 分钟 ELISA Enzyme-linked immuno sorbent assay 酶联免疫吸附测定 SEM scanning electron microscope 扫描电子显微镜 DIC Disseminated Intravascular Coagulation 弥漫性血管内凝血 MODS Multiple Organ Dysfunction Syndrome 多器官功能障碍综合征 2 The role of syncytiotrophoblast microvillous membrane in Pre-eclampsia Abstract Background and goals: Pregnancy-induced hypertension is a idiopathic disease in The Obstetrics. It occurs in 5%-8% of normal pregnancy, makes the fatality rate nearly 10%-16% in all. Through many scientists’ efforts of decades , now it etiology still is unkown, but there are a huge improvement in “vascular endothelial injury theory”.two pathophysiological stage—1. disturbed placental function in early pregnancy include Impaired trophoblast invasion and remodelling of the spiral artery. 2. The toxic factor shed from placenta damage vascular endothelial , enhanced maternal intravascular systemic inflammatory response include hypertension, proteinuria, hypercoagulable state. The toxic factors release from placenta play a key role in the etiology of PE .Now some scientists assume PE is a placental disease. Normal third trimester pregnant women has a hyper-coagulation , APTT、PT were shortened, FIB was elevated, it prevent women from haemorrhage . PE have a higher hypercoagulable state than normal pregnant women,endogenous coagulable pathway ,as the exogenous coagulable pathway, be activated. APTT、PT were both dramatic shortened. In first trimester, PE appear hypercoagulable state, it earlier than any clinical features and other laboratory index. HELLP is a serious complication of PE. It has PLT＜50×109/L、 elevated enzyme of liver、hemolysis, it’s a serious type of PE induce coagulable state. Although there are many evidences to identify the hyper-coagulable state of PE, there have no research about the mechanism of PE’s hyper-coagulable state. There have a common view: the increase of