Oral Microbiology 口腔微生物学.ppt

Oral Microbiology 口腔微生物学 口腔医学院： 亓庆国 College of Stomatology : Dr.QI Qingguo 联系方式 亓庆国 博士 副教授 口腔内科教研所 主任 qqg@sdu.edu.cnLab)Clinic) Introduction Microbes -- most widely distributed ,old living culture on earth 1013 ：1014 口腔微生物学的研究内容 Oral microflora : colonization development reproduce metabolism human health and disease The oral microflora in health and disease Natural microflora The relationship between naturak microflora and hosts (harmonious) The balance were broken when: 1 major changes to the biology of the mouth from exogenous sources 2 alterations in the integrity of the host defences 3 the presence of the microbes at the sites not normally accessible to them. 关键问题 口腔正常菌群如何转化为条件致病菌，从而导致口腔疾病的发生 是目前和未来很长一段时间内口腔微生物学研究的关键问题和研究方向 口腔中的微生物种类 Oral microbes Dental plaque Significance Oral microbes ---Oral disease common disease --- dental caries /periodontal disease/oral mucosal disease /other disease Dental caries Periodontal disease Mucosal disease The oral microflora and general disease 1 oral microorganisms can impact on the general health of an individual. Periodontal pathogens, host’s immunological response , may be risk factors for cardiovascular disease, preterm or low birth weight babies. Oral microflora and general health Oral bacteria can act as opportunistic pathogens at distant sites in the body, e.g following entry to the blood stream, or aspiration into the lungs. The mouth also can act as a reservoir for the pathogenic bacteria , such as P.a History of Oral microbiology The golden age of microbiology Secondary stage Return to Plaque as a biofilm 主要讲授内容 Reference books 口腔生态学 周学东 胡涛 主编 口腔疾病的微生物学基础 刘天佳 主编 牙周病微生物学 李德懿 主编 口腔微生物学 周学东 肖晓蓉 主编 口腔生物学 樊明文 主编 口腔生态系的特点 Characteristics of Oral Ecosystem Ecosystem 生态系 生态系：生物与生物之间 以及生物与环境之间的关系 生态学:研究生物与环境之间的相互依赖和相互制约的科学 口腔生态系:口腔组织器官与微生物群 口腔生态学:阐述的是口腔组织器官与微生物群之间各种相互作用的生理平衡态与病理失调态的机理 Oral ecosystem 口腔生