和胃冲剂对胃肠动力影响的实验研究-内科学专业论文.docxVIP

计学差异(P0．05)，其中含阳春砂和胃冲剂对胃肠促进作用优 计学差异(P0．05)，其中含阳春砂和胃冲剂对胃肠促进作用优 于另两种；不同剂量该冲剂作用相近，无明显统计学差异(P 0．05)。2．左旋精氨酸和左旋麻黄碱均可导致小鼠胃内残留率增 高，小肠推进比减低。和胃冲剂+左旋精氨酸组与左旋精氨酸组 相比胃内残留率减低、小肠推进比增高(P0．05)，与蒸馏水组比 较无显著性差异(P0．05)；和胃冲剂+左旋麻黄碱组与左旋麻 黄碱组比较对小鼠胃肠动力的影响无统计学差异(P0．05)，两 组与蒸馏水组相比胃肠动力显著减弱(P0．01)。和胃冲剂组血 浆胃动素(122．90±33．14pg／nd)水平高于蒸馏水组(87．25 4-14． 75 pg／m1)(P0．05)，两组相比血清一氧化氮水平差异无统计学 意义(P0．05)。3．急性毒理实验中小鼠最大耐受倍数为240， 未见中毒症状或死亡现象发生。j 结 论 1．和胃冲剂能有效地促进正常小鼠胃肠动力。三种冲剂胃 肠促进作用依次为：含阳春砂和胃冲剂含绿壳砂和胃冲剂含 缩砂和胃冲剂。增大和胃冲剂剂量，促胃肠动力作用无明显增强。 2．和胃冲剂能改善L．精氨酸引起的胃肠运动障碍；对左旋麻 黄碱引起的胃肠运动障碍无明显影响。和胃冲剂可以升高血浆胃 动素水平；调节正常鼠的血清一氧化氮水平。 3．本冲剂小鼠最大耐受倍数240，可认为其无明显急性毒副 作用。 关键词：和胃冲剂；砂仁；胃肠动力；胃动素；一氧化氮 ·2· Experimental Experimental Study of the Effect of Heweichongji on the Gastrointestinal Motility Postgraduate：Zhang Qingfang Superviser：Li Yan ABSTRACT Objective To investigate the effect of the Heweichon西i(HWCJ，composing of alnomum，chicken gi=ard meInbrane，medicated leaven and malt) 013．the gastrointestinal motility of normal and dysmotility rats，to select the best among HWCJs containing three different aI／lOmllll respective— ly，and to study its influnces on the plasma motilin and nitric oxide of rats as well as its acute toxicity． Methods All experimental animals were fed for one week．The gastric emptying and small intestinal propulsion were observed by the method of nutritional semi—solid feeding．Dysmotility models Wele induced by in廿apefitoneal injection of L-argine or L—ephedrine．Radioimmunoas- say and Griess method were used to determine motilin and nitric oxide in experimental animal plasma respectively．The toxicity WaS evaluated by mea．1n8 of max endured multiple． ·3- ResultsCompared Results Compared with negative control，the gastrointestinal motility of all kinds of HWCJs was significandy improved(P0．05)．There was no statistical difference between HWCJ and Cisapfide(P0．05)as well as among different kinds of HWCJs(P0．05)，however the drug with ainomunl vinosum lout Was better than others．The gastrointesti— nal motility did not significa