和血益智方抗大鼠血管性痴呆作用及机制研究-中西医结合基础专业论文.docxVIP

和血益智方抗大鼠血管性痴呆作用厦机制研究 和血益智方抗大鼠血管性痴呆 作用厦机制研究 英文摘要 The study of the effect and the mechanism on vascular dementia rats after HuoXueYiZhi Recipe Abstract As we known，Vascular Dementia(VD)is kind of diseases which the elder were suffered easily after apoplexy．VD patients’symptoms various which is coneemed with the place、the area and times of injury the brain．MoSt VD patients have lost their capability of memory and learning and calculating．VD has been of the most active study fields all the world． Although more and more researches show the morbidity of Vascular dementia (VD)arise，its mechanism has not been understood completely．In years， studies of the Chinese Medicine therapy of VD have been shown the medicine papers and magazines．Some Chinese Medicine could inerease the blood flow：of the brain microvascular vesseI and improve Iearning and memory capability of VD patients．According t0 the theories ofTraditional Chinese Medicine and the papers of clinic studies，the study choosed the HuoXueYiZhi Recipe(contained Radix Angelicae sinensis，Rhizoma Chuanxiong，Radix Paeoniae Alba，Radix Rehmanniae． Radix Astragali、Herba Ecliptae、Fmctus Ligustri lucidi、Fructus Alpiniae oxyphyllae、Pofia Radix pini、Radix polygalae、Rhizoma pinelliae preparatum) to treat the Vascular Dementia Model of rat(VDM)．The study used VDM was fomaed by 2．vessel occlusion method and VDM was successful reproduced．It could copy the elinical feature of human VD and showed clearly the defection of learning and memory． SpatiaIlearning and memory of VD rats were tested by Morris Water Maze and Shuttle after month treatment of HuoXueYiZhi Recipe．At the same time the concentration Estrongen(estradiol、and ACTH in blood and tissue were tested and Hippocampal were compared． The conclusions of the study showed HuoXueYiZhi Recipe could improve the learning and memory of VD rats and protect hippocampal from injury．The effects were related to the concentration Estrongen and ACTH in blood higher．It may be regulate the nerv