高分子量PDLLA的合成研究-材料学专业论文.docxVIP

武汉理工大学硕士学位论文ABSTRACT 武汉理工大学硕士学位论文 ABSTRACT Polylactide is of polymer materials that have good biocompatibility and poisonousness be degraded by organisms．The application of Polylactide and its copolymers is increasing in the fields of biomaterial， especially in the tissue engineering scaffold material，carrier for pharmaceutical release and internal fixation of bone fracture．The development of PLA and synthesis of its monomer——一lactide catching more attention in this field．The cost oflactide iS ofthe most important factors that hamper the PLA from widely for long time．In this paper series of apparatus which boost the product ratio to the utmost was focused on．Meanwhile the factors affecting the molecular weight of PLA in the polymerization were also discussed． Once the manufacture of polylactide is industrialized，it be of wide application in the fields of medicine materials and degraded plastics without doubIt． This apparatus was designed based summarizing the most synthetic processes of lactide presently．The reduced pressure distillation was choosed and improved to obtain lactide with high product ratio．The product ratio was increased to 45％from 30％．Furthermore，lactide was recycled from the ethyl acetate recrystallization solution，and structure was investigated with IR and UV spectrum．The result indicated that the process is suitable and feasible，and the product ratio is beyond 40％． Firstly,through analysis for the synthetic mechanism of lactide and according to improve the condition of synthetic process the factors related were studied in detail．These factors included the amount of activator，temperature and time of dehydration，temperature and time of depolymerization，pressure of the vessel a1．The optimal synthetic condition and process engineering were draw ultimately．The optimal dehydration temperature is 140℃，dehydration time is 4 hours，dehydration amount reach 94％，depolymerization temperature is 240C， depolymerization time is 2 hours and finish 2700． Secondl