不同种类雌激素对缺血性卒中的作用与CREB的相关性.pdfVIP

温州医学院硕士学位论文 between ontherole Theassociation of different．typesestrogen strokeandCREB’S ofischemic Abstract of has moreandmore neuroprotectionestrogengain a_ttention，many Objective：11le showedthat hada effectonischemicstroke．Inorderto studies estrogen protective theeffectof onischemicstrokeandthemechanism．Inthefocalcerebral discuss estrogen rat useddifferentof to CREB ischemia model，we types estrogenpretreatment，observe and in andsubventricularzoneintheratinorderto pCREBchangesllippocampus for treatmentischemicstroke． moretheoreticalbailsthe of provide estrogen Methods：28SDfemalerats dividedinto7 used(230-2509)，wererandomly groups． Model 7a-estradiol groupGroup：1 group，estronegroup，1713一estradiolgroup，estriolgroup． Thecontrol ineach tOestablishthe group．Ratsgroup group：oilgroup，salinegroup，sham thesham ofnormal afterthe correspondingmodel．Expectgroup，Eightdays feeding ofbilateral thel OVX,we 7a-estradiol，estrone，estriol，1713-estradiol， operation injected saline ontherats forfourteen focalischemic oil，and subcutaneouslydaily days，then strokemodelwasmadeMCAO was feededfor