心肌细胞周期调控研究进展.PDFVIP

6 4 ( ) 生命科学研究 Vol. 6 No.4(Suppl.) 200212 Life Science Research Dec. 2002 X 曹 磊, 王跃群, 吴秀山 ( , 410081) : 尽管分子心脏学在很多方面已经取得了较 的进展,但是有关心脏形成细胞的起源诱导心脏发生的 机理胚胎期和成人期心肌细胞增殖的调控途径仍然不是很清楚.在最近的研究中,人们对心肌细胞周期调控 已有所了解.主要就心肌细胞周期活动和成人心肌细胞发生的研究进展进行了综述. : 心肌细胞增殖; 心脏再生;基因打靶; 转基因鼠 : 253 :A : 1007-7847(2002) S1-0054-04 Advances in Regulation of Cardiomyocyte Cell Cycle CAO Lei, WANG Yue-qun, WU Xiu-Shan ( College of Lfi e Sciences, H unan Normal Univ ersity , Chang sha 410081, H unan , China) Abstract : Although rapid progress is being made in many areas of molecular cardiology, theorigins of heart-forming cells, themechanisms responsible for cardiogenic induction, and the pathway that regulate cardiomyocyte prolifera- tion during embryonic and adult life remain unanswered.A progress in recent research on cardiomyocyte cell cycle regulation has been made.A review of cardiomyocyte cell cycle activity and de novo cardiomyogenesis in adult is then presented. Key words: cardiomyocyte proliferation; heart regeneration; gene targeting; transgenic mice (Lfi e Science Research ,2002,6(Suppl) :54~ 57) ., 1 , , . .E8 B- DNA ( 70%) .E11( : ,, )45%.