新生儿苍白球磁共振成像T1WI信号升高的原因分析.docVIP

DOI：10.16016/j.1000-5404.201503107 新生儿苍白球磁共振成像T1WI信号升高的原因分析 廖懿，蔡金华，郑鹤琳（400014重庆，重庆医科大学附属儿童医院放射科、儿童发育疾病研究教育部重点实验室、儿科学重庆市重点实验室、重庆市儿童发育重大疾病诊治与预防国际科技合作基地) [摘要] 目的 探讨新生儿苍白球磁共振成像T1加权（T1WI）信号对称性升高的原因。方法 回顾性分析427例新生儿磁共振图像，对苍白球T1WI信号进行定性和定量。苍白球T1WI信号升高与各种临床病因之间的关系采用logistic回归分析，同时分析苍白球/大脑皮质T1WI信号强度比值与血清总胆红素(TSB)水平、日龄之间的关系。结果 427例中249例（58.3%）出现苍白球不同程度的T1WI信号升高；logistic回归分析显示高胆红素血症的回归系数=1.777，OR值=5.915（P＜0.001）；290例高胆红素血症中209例（72.1%）出现苍白球T1WI信号升高，137例无高胆红素血症者中40例（29.2%）信号升高。进一步分析显示随着TSB水平的升高，苍白球/大脑皮质信号强度比值有升高趋势，差异有统计学意义（χ2=84.734，关联性系数r=0.407，P＜0.001）。相关性分析表明苍白球/大脑皮质信号强度比值与日龄呈负相关（r=-0.441，P＜0.001）。结论 新生儿苍白球T1WI信号升高主要由TSB水平升高引起，可能还与其他因素有关。 [关键词] 苍白球；胆红素；磁共振成像；新生儿 [中图分类号] R445.2 [文献标志码] A Analysis of hyperintensity of the globus pallidus on T1-weighted magnetic resonance images in newborns Liao Yi, Cai Jinhua, Zheng Helin (Department of Radiology, Children’s Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; Key Laboratory of Pediatrics in Chongqing; Chongqing International Science and Technology Cooperation Center For Child Development and Disorders, Chongqing 400014) [Abstract] Objective To explore the causes of symmetric hyperintensity of the globus pallidus on T1-weighted (T1WI) magnetic resonance images in newborns. Methods The brain magnetic resonance images of 427 cases of neonates were reviewed, and the T1WI signal patterns of the globus pallidus were qualitatively and quantitatively analyzed. Logistic regression analysis was applied to investigate contributions of the clinical factors to the hyperintensity of globus pallidus on T1WI. The signal intensity ratio of globus pallidus to cerebral cortex was compared with the total serum bilirubin (TSB) levels and the postnatal age at examination. Results T1WI hyperintensity of the globus pallidus was found in 249 of 427 cases (58.3%). Logistic regression analysis showed that regression HYPERLINK C:/Users/Administrator/AppData