氯吡格雷抵抗与对策.pptVIP

434例患者CYP2C19等位基因频率分布 * 434例患者CYP2C19基因型频率分布不同性别CYP2C19基因型和等位基因频数频率分布 * 434例患者CYP2C19代谢型频率分布 * 血小板聚集的抑制: Onset References Gurbel PA, Bliden KP, Butler K, et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of 替格瑞洛 versus 氯吡格雷 in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation. 2009;120:2577–2585. * In Period 1 (14 ± 2 days), the last dose of study drug was administered in the morning. In Period 2 (14 ± 2 days), all nonresponders switched treatment. All patients received concomitant aspirin therapy (75 to 10