原发性失眠症患者认知功能与生活质量的分析.doc

中文摘要 原发性失眠症患者认知功能与生活质量的研究 害。（2）病程的长短，病情的严重程度以及伴发的焦虑抑郁情绪是导致认知功能损害 的相关影响因素。（3）原发性失眠症患者的生活质量在生理、心理、独立性、社会关 系、环境等维度和总体生活质量都有显著降低。（4）失眠所伴随的焦虑抑郁情绪，失 眠的严重程度和有无家族史是影响原发性失眠症患者生活质量的主要因素。 关键词：原发性失眠症；认知功能；神经心理学；生活质量 作 者：陈美玲 指导老师：兰光华 II A study on cognitive function and quality of life in PI patients Abstract A study on cognitive function and quality of life in patients with primary insomnia Abstract Objective: (1) To explore the characteristics of cognitive function impairment and its influencing factors in the patients with primary insomnia (PI), so we can provide the neuropsychological basis for the study of cognitive function of PI patients. (2) To explore the quality of life (QOL) and its influencing factors in patients with primary insomnia, so we can provide scientific evidence for improving the quality of life of PI patients. Methods: (1) Neuropsychological tests including Wechsler memory scale (digital accumulation, visual recall, visual reproduction, associative learning), digit span, digit cancellation, trail-marking test (TMT), Wisconsin card sorting test (WCST) were used to evaluate the attention, memory and executive function in 46 PI patients (PI group) and 40 healthy controls (HC group); (2) The WHOQOL-BREF was used to assessed the quality of life in 50 PI patients and 40 healthy controls; (3) The severity of insomnia and its accompanying anxiety or depression symptoms in PI patients were separately assessed by Pittsburgh sleep quality index (PSQI), Self-rating anxiety sale (SAS) and Self-rating depression sale (SDS). Results: (1) The cognitive function and its influencing factors in PI patients: ? Compared with the healthy controls, the achievements of digit accumulation, visual recall, visual reproduction, associative learning, digit span backward, the error rate of digit cancellation test, trail-marking test B and B-A and Wisconsin card sorting test (WCST) were significantly worse in the PI patients except the correct responses of WCST. ? In the PI patients, t