IGF-1、IGF-1R和IGFBP-3在非小细胞肺癌患者血清中的表达及临床意义.doc

IGF-1、IGF-1R和IGFBP-3在NSCLC患者血清中的表达及临床意义 高志强，储天晴，赵怡卓，韩宝惠 上海交通大学附属胸科医院，呼吸内科 200030 （本研究受上海交通大学医学院科技发展基金项目11XJ-21065及辉瑞公司IIR项目WS551485资助） [摘要] 目的：检测胰岛素样生长因子-1（IGF-1）、胰岛素样生长因子受体-1（IGF-1R）与胰岛素样生长因子结合蛋白-3（IGFBP-3）在非小细胞肺癌（NSCLC）患者血清中的表达, 并探讨其主要问题的回复，已删除“ 主要问题的回复，已删除“诊断及预后”等内容 方法：运用酶联免疫吸附法(ELISA) 检测154例NSCLC患者, 44 例健康人外周血血清中IGF-1、IGF-1R和IGFBP-3的水平。 结果：NSCLC组血清IGF-1及IGF-1R 表达显著高于健康组( P0.01) , IGFBP-3 表达显著低于健康组(P0.05) 。IGF-1, IGF-1R,IGF-1/IGFBP-3 , IGF-1R/IGFBP-3 在有淋巴结转移、远处转移及TNM III-IV期的NSCLC患者中明显高于无转移者及TNM I-II期者( P0.05) , 而IGFBP3 下降明显高于无转移者及TNM I-II期者( P0. 05) 。NSCLC组IGF-1、IGF-1R与IGFBP-3 浓度呈负相关 (P0.05) 。 结论：NSCLC患者血清IGF-1、IGF-1R及IGFBP-3 表达在NSCLC的发生、发展及远处转移中起重要作用主要问题的回复，已删除“ 主要问题的回复，已删除“诊断及预后”等相关内容 [关键词] 非小细胞肺癌；胰岛素样生长因子1；胰岛素样生长因子1受体；胰岛素样生长因子结合蛋白3；酶联免疫吸附法 [中图分类号] R734. 2 [文献标识码] B Clinical Significance of IGF-1,IGF-1R and IGFBP-3 in Serum of Patients with Non-small Cell Lung Cancer Gao Zhiqiang,Chu Tianqing, Zhao Yizhuo, Han Baohui (Department of Pulmonary Medcine，Shanghai Chest Hospital, Shanghai Jiao Tong University，参照本院科教科要求，单位英文署名已更新Shanghai 200030，P.R.China) 参照本院科教科要求，单位英文署名已更新 [Abstract] Objective: To investigate the expressions of Insulin like growth factor-1 ,Insulin like growth factor-1 receptor and Insulin like growth factor binding protein-3 in serum of patients with non-small cell lung cancer, and discuss the clinical value主要问题的回复，已删除“ 主要问题的回复，已删除“诊断及预后”等内容 Methods: The serum were collected in 154 cases of non-small cell lung cancer and 44 cases of health. The expression of IGF-1,IGF-1R and IGFBP-3 in serum were analysed by ELISA. Results: The expression of IGF-1 and IGF-1R of lung cancer group were significantly higher than those of health group( P0.01) ; but the IGFBP-3 levels were significantly lower than that of health group( P0.05) . IGF-1, IGF-1R,IGF-1/IGFBP-3 and IGF-1R/IGFBP-3 in serum were higher in patients with lymphoid node metastasis or metastasis or TNM III-IV than those without Metastasis or TNM I-II( P0.05) , and IGFBP-3 levels were signi