异香豆素类化合物的合成研究及新进展-南京师范大学学报.PDF

5 2 () Vo.l 5 N o. 2 2005 6 JOURNAL OF NAN JING NORMAL UN IVERSITY ( ENGINEERING AND TECHNOLOGY) Jun. 2005 异香豆素类化合物的合成研究及新进展 李 丽, 杨锦飞, 袁相爱 ( , 210097) [] , , , . . . [] , , [] O623. 52, [] B, [] 2005) Study on Syn thesis of Isocoum arins and its E volution L I L,i YANG J infe,i YUAN X ianga i ( School of Ch em istry nd Environm ent Science, N njing Norm lUn iversity, J i ngsu N njing 210097, Ch in ) A bstract: The rticle introduces the nti tumor nd other ph rm cologic effects of the isocoum rins, reviews the m ethods of synthesizing isocoum rins, nd pl ces n em ph sis on introducing nd comp ring such m ethods of synthe sizing syntheticroutes of d ihydroisocoum rins s ozone ox id tion, org nic m et l sythes is, c t lytic ox id tion nd so on. The rticle lso m kes prelmi in ry investig tion of the synthesis of poly subtituedisocoum rin, nd fin lly sug gests n expect tion for its prospect in phy siologic l nd biologic l ctivity. K ey w ord s: isocoum rin, synthes is, bio ctivity [ 2] (: 1H21) 1985, Furut ( 1 ), , , , ( 2 ) . 1989, K end ll [ 5] , , ( 1b)( 2b) . [ 1] . [ 2] [ 3] [ 4] , , . , , . . 1 二氢异香豆素类化合物的合成 . . 1. 1 1. 2