血管紧张素Ⅱ受体拮抗剂联合中成药治疗慢性肾炎蛋白尿的-医学信息.PDF

医学信息2018 年9 月第31 卷第17 期 Medical Information Sep. 2018 Vol. 31 No.17 述 管紧张素Ⅱ受体拮抗剂联合中成药治疗 慢性肾炎蛋白尿的研究进展 文君 首都医科大学燕京医学院袁北京 101300冤 摘 要 慢性肾炎基本临床表现为蛋白尿尧血尿尧高血压尧水肿袁其中蛋白尿是加速肾小球硬化尧促进肾功能恶化的重要因素之 一袁且蛋白尿水平越高袁导致肾脏病进展的速度越快袁因此积极降低蛋白尿是肾脏病治疗的关键遥 血管紧张素 受体拮抗剂除 降压作用外袁还有降低患者蛋白尿水平及肾脏保护作用袁为进一步减少慢性肾炎蛋白尿袁在 用ARB 基础上加用中成药亦可 获得疗效进行综述遥 关键词 血管紧张素 受体拮抗剂曰中成药曰慢性肾炎蛋白尿 中图分类号 R473.6 文献标识码 A DOI 10.3969/j .issn.1006-1959.2018.17.015 文章编号 1006-1959 2018冤17-00450-04 Advances in Research of Angiotensin II Receptor Antagonist Combined with Chinese Patent Medicine in the Treatment of Chronic Nephritis Proteinuria CUI Wen-j un (Yanji ng Medical College,Capital Medical University,Beij ing 101300,China) Abstract The basic clinical manifestations of chronic glomerulonephritis are proteinuria,hematuria,hypertension,edema,among which proteinuria is one of the important factors to accelerate glomerulosclerosis and promote the deterioration of renal function,and the higher the level of proteinuria,the faster the progress of kidney disease.Therefore,active reduction of proteinuria is the key to the treatment of kidney disease.Angiotensin II receptor antagonists,in addition to antihypertensive effect,also reduce the level of proteinuria and renal protection in patients,in order to further reduce chronic nephritis proteinuria,the use of ARB based on the addition of proprietary Chinese medicine can also be obtained. Key words Angiotensin II receptor antagonist;Chinese patent medicine;Chronic nephritis proteinuria （ ， 慢性肾炎 chronic glomerulonephritis ）起始致病 及 AT4 四种亚型 Ang 主要作用于AT1 发挥其