阿德福韦酯多晶型研究化学工程专业论文.docxVIP

ABSTRACTPolymo印hs ABSTRACT Polymo印hs existing in drug system haVe锄i11nuence on mal(ing tecllll0109y， qual时a11d s切blition．DiVerse physical aIld cheIIlical propeIrties of polymo印hs coIulect 埘th bioavailability．ComrolliIlg polymo印hs become an essentialissue on廿le咖dy of drugs．Polymo印hs aspects、vere c硎ed out in this p印er，aIld adefoVir dipiVoxil was chosen aS tlle research system，Ⅱle detailed、Verefollowed． Fom-I a11d V was prepared by using solVent-out c巧stallization metllod，Fom-IX cooling c巧stallization．Tlle quamitatiVe a11alysis of铆o foms adefoVir dipiVoxil mix仙re was meaSuredby Di疏rential scaIllljng calomet巧，Powder X-ray di胁ction a11d R锄aIl spec们meter．Tllen，t11e calibration cuⅣe waS bu o quanti匆the aIIlo嘁of V and I-fonn adefoVir dipiVoxil in po、Ⅳder mixture．The optimized method waS coInpared by calculating relatiVe deViation I己E． 111e solubility of铆o fonIls adefoVir dipiVoxilin mixed solvates which include n-hexalle aIld methylene chloride according to Volume ratio 1 2：1 waS meaSured by a dyn锄ic metllod． The solubili锣 data is coHelated by experience fo珊ulation， then，estimatedentllalpy a11d en仃opy of dissolution of two fomls based on regression of the line． Non-isotllemal t11emograVime廿y was applied to study t11e t11enllal decomposition processes of adefoVir dipiVoxil I-fb珊，Ⅵ粗ch inClude tllrlee mennal decomposition stages， tllemal decomposition process waS just adefoVir dipiVoxilb啪ing．By getting actiVation energy E aIld mechaIlism mnction g(0c) reSpectiVely witllout any imegral error，decomposition mechallism aIld l(inetics缸lction of eVer)，Stage were obtained． In order t0 explore growmmect吼ism，me metaStable zone arld iIlmlction time waS measured．The innuence factors of metastable zone contajn cooling Speed and agitation speed， tlle effect of teInperature and supersaturation on induction time were inVestigated．Atlast，Nucleation mechallismwaS sured on t11e baSis of fitting以S)and(h1S) ‘2 correlation coe伍cient R2． Foms component and solution conce心ation of ad