阿魏酸钠对野百合碱诱导肺动脉高压大鼠的保护作用内科学专业论文.docxVIP

缩略语Analysis 缩略语 Analysis of variance(ANOVA)：方差分析 Cyclic guanosine monophosphate(cGMP)：单磷酸环鸟苷酸 Chronic obstruct ive pulmonary di sease(COPD)：慢性阻塞性肺病 Endothel ial ni tri c oxi de synthase(eNOS)；内皮型一氧化氮合酶 Endothelin一1(ET-I)：内皮素一1 Ferul ic acid(FA)：阿魏酸 Monocrotaline(MCT)：野百合碱 Ni tric oxide(NO)：一氧化氮 Pulmonary artery hypertension(PAH)：肺动脉高压 Pulmonary artery pressure(PAP)：肺动脉压 Right ventricle systol ic pressure(RVSP)：右室收缩压 Sodium ferulate(SF)：阿魏酸钠 The ratio of right ventricular weight to weight of the left ventricle plus septum(RV／(LV+S))：右室／(左室+室间隔)重量之比 博士研究生学位论文 博士研究生学位论文 北京协和医学院 秦春常 Sodium ferulate attenuated pulmonary medal hypertension in monocrotaline Background：Pulmonary arterial hypertension is a fatal disorder that is associated with remodeling of the pulmonary vasculature．Endothelial dysfunction plays an important role in the progression of pulmonary arterial hypertension．Previous studies showed that sodium femlate can improve endothelial function by increasing nitric oxide(NO)production．Sodium ferulate has antithrombotic，platelet aggregation inhibitory and antioxidant activities．We hypothesized that daily supplemenation of sodium fcrulatc attenuate monocrotaline induced pulmonary artery hypertension in Methods：Our hypotheses Was tested in a modle of pulmonary arterial hypertension induced with monoerotaline in rats．Fifty rats were randomly divided into four groups： normal control(treated with salk and distilled water,n=8)，other rats received monocrotaline injection were randomly assigned to preventive group(treated with sodium ferulate，n=12)，positive control group(treated with distilled water,IFl5)and treatment group(treated with distilled water then with sodium fcrulate，n=1 5)．We measuered the right ventricular systolic pressure，the ratio of right ventricular weight tO weight of the left ventricle plus septum．We investigated the changes in the expression of endothelial nitric oxide synthase(eNOS)in lung