肥胖相关表型的预测及其遗传相关性动物学专业论文.docxVIP

BF％的狭义遗传率(矿)都很显著的(仄O．001)，分别为O．38， BF％的狭义遗传率(矿)都很显著的(仄O．001)，分别为O．38， 0．39，0．43。并且BF的共同家系效应较小，BF％的共同家系效应接近 为零且不显著。双变量遗传分析显示BMI与BF，BF96之间的既，几 和邝也都相当显著(仄0．001)，并且BMI与BF和BF％之间的几， 耽 和 所对应数值分别为0．859， 0．900， 0．884和 O．695，0．829，0．773。BMI和BF及BMI和BF％共同遗传变异分别是 73．8％，48．3％。相比BMI和BF、BF96的共同遗传变异，BF和BF％的 共享遗传变异更高(80．6％)。中国女性中的结果暗示躯干脂肪随年龄 变老有增加的趋势；年龄对躯干脂肪和所研究的人体测量学指数有明 显的影响；组合使用5个人体测量学指数预测躯干脂肪比起单独使用 它们来预测精确性更高。白种人中的研究结果揭示了BM工和BF，BF96 之间的绝大部分变异是由于共同的遗传和环境因子引起的。而且，对 遗传相互作用的认识和梳理使我们对体重指数和身体脂肪之间的关 系有了更好的理解。 关键词：肥胖症，人体测量学指数，躯干脂肪，全身脂肪，主成分 分析 Abstract0besity Abstract 0besity caused by excess body fat is becoming a worldwide noticeable problem． Common overall obesity and trunk obesity， which results from a complex interaction of environmental and genetic factors， is associated with an increased risk of metabol ic di seases． Therefore， the early measurement of fat mass has potential importance to evaluate obesity． Significant anthropometric indices， such as body mass index (BM工)，waist circumference (WC)， hip circumference (HC)，waist—to—hip ratio (WHR)， conicity index (CI)， are several surrogate phenotypes to assess body fat (BF)， percent body fat (B F1％) and regional fat mass．Considering the characteristics of rapid， cheapness and val idity， a number of researchers haVe used one or more above indices in obesity—related genetic and epidemiologic studies focus on Caucasians and various results were inconsistent about the accuracy of evaluating body fat by these indices．Additionally， the common genetic determination of BF and BM工used frequently in studies rarely is explored． The present study has two objectives：the first is to eValuate the correlation and prediction of trunk fat mass (FMtrunk) with five anthropometric indices by and principal component analysis (PCA) and multiple regression analyses in Chinese Han—ethnic females． The other is to determine genetic correlation (％) environmental correlation (pF)， and phenotypic correlation(pP)between BM工and BF，BF％by the