葛黄颗粒对酒精性肝病模型大鼠的防治作用及其机制研究中西医结合临床专业论文.docxVIP

中的含量明显下降(P0．05)，中、低剂量组较模型组下降不明显 中的含量明显下降(P0．05)，中、低剂量组较模型组下降不明显 (Po．05)，高剂量组与对照组之间无显著差异(P0．05)。 结论：1、梯度白酒灌胃法联合高脂肪饲料喂养法成功建立起了 酒精性肝病大鼠模型。2、葛黄颗粒可以降低酒精性肝病大鼠模型血 清中ADH含量，提高ALDH含量，通过促进乙醇代谢，防止肝脏受 损，从而降低血浆乙醇浓度，起到有效的降醇解酒作用，减轻酒精对 大鼠机体及肝脏的损害。3、葛黄颗粒可以明显降低酒精性肝病大鼠 模型中内毒素的含量，调控细胞因子IL．1 13、IL一6、TNF 0【、瘦素、 脂联素等，抑制肝脏炎症反应，减少促炎因子、细胞外基质等的产生 和沉积，有效阻断酒精性肝病病变进一步发展。 关键词：葛黄颗粒：酒精性肝病；内毒素；细胞因子 万方数据 Study Study on the protective effect and mechanism of Ge Huang Granule On rats with alcoholic liver disease Abstract：Objective：to use with sun Jiao，treatment of alcoholic liver disease(alcoholic liver disease，ALD)experience prescription gehuang Granule”on rat model of alcoholic fatty liver intervention，by observing the rat serum index changes and pathological changes，a preliminary study of Ge Huang granule in preventing and treating alcoholic fatry liver may be involved in the mechanism． Methods：selected 1 08 male and female SD rats，divided them for six groups：gehuang granule low dose group(10w dose group)，Ge Huang particles in the dosage group(middle dose group)，particle Ge Huang high dose group(high dose group)，the United States metadoxine in the positive control group(positive control group)，model group and normal group(n=1 8)．The rat model of alcoholic fatty liver was prepared by the method of gradient liquor filling and high fat diet．The anhydrous ethanol disposition into 30％，35％and 40％concentration，high，of medium，low， model group and positive control group in accordance with the 1．0m1．1 009-1．d一1 dose respectively irrigation stomach 1，1，1 0 weeks．At the same time from the first weeks of the start to the end given every other day hi曲fat diet and normal group were given the same volume of distilled water irrigation stomach and ate a normal diet．After 4 weeks of high，medium and low dose group were treated with high，middle and low ，4． 万方数据 dose dose of gehuang granule，while the control group was given the beauty of metadoxine in gavage．Lasts 8 weeks after sacrificed all the rats．HE staining