甘精胰岛素、格列美脲片、阿卡波糖片联合治疗磺脲类药物治疗失效糖尿病疗效分析.docxVIP

甘精胰岛素、格列美脲片、阿卡波糖片联合治疗磺脲类药物治疗失效糖尿病疗效分析 　　[摘要] 目的 探?甘精胰岛素、格列美脲片、阿卡波糖片联合治疗磺脲类药物治疗失效糖尿病的疗效。方法 方便选择XX年1―12月该院收治的96例磺脲类药物治疗失效的糖尿病患者作为研究对象，采用随机数字表作为分组原则将其分为对照组与研究组，每组48例。对照组采用甘精胰岛素联合格列美脲片治疗，研究组在此基础上口服阿卡波糖片治疗。观察对比两组治疗前与治疗后血糖水平与胰岛功能指标、每日胰岛素用量、24h血糖达标时间及低血糖的发生率。 结果 研究组治疗后空腹血糖mmol/L、餐后2 h血糖mmol/L、糖化血红蛋白%、胰岛素抵抗指数均低于对照组mmol/L、mmol/L、%、，差异有统计学意义，胰岛β细胞功能指数高于对照组，差异有统计学意义。研究组平均每日胰岛素用量为U/d，低于对照组U/d，差异有统计学意义。研究组24 h血糖达标时间h，高于对照组h，差异有统计学意义。研究组低血糖发生率%与对照组%对比差异无统计学意义。结论 甘精胰岛素、格列美脲片、阿卡波糖片联合治疗磺脲类药物治疗失效糖尿病疗效确切，可以有效改善患者的血糖水平，强化胰岛功能，适于临床推广。　　[关键词] 甘精胰岛素；格列美脲片；阿卡波糖片；磺脲类药物；失效糖尿病　　[中图分类号] R5 [文献标识码] A [文章编号] 1674--0120-03　　Efficacy of Insulin Glargine， Glimepiride Tablets and Acarbose in the Treatment of Diabetes Mellitus with Sulfonylureas　　ZHANG Guo-hua　　Western Medicine Center， Ji’nan Central Hospital Affiliated to Shandong University， Ji’nan， Shandong Province， China　　[Abstract] Objective This paper tries to investigate the effect of insulin glargine， glimepiride tablets and acarbose tablet combined treatment of sulfonylurea therapy failure in diabetes patients. Methods 96 patients with diabetes mellitus treated with sulfonylurea in this hospital from January to December XX were convenient selected and randomly divided into control group and study group with 48 cases in each group. The control group were treated with insulin glargine combined glimepiride tablets treatment， research group on the basis of oral treatment of acarbose tablet. The levels of blood glucose and islet function， daily insulin dosage， the time of 24 h blood glucose and the incidence of hypoglycemia before and after treatment were observed and compared between the two groups. Results The fasting blood glucose mmol/L， postprandial blood glucose mmol/L， glycosylated hemoglobin% and insulin resistance index were lower in the study group than those in the control group mmol/L， mmol/L， %， ，difference are statistically significant. The beta cell function index was higher than that of the control group . The study grou