医学毕业原发性干燥综合症患者血清il.docxVIP

XX大学 毕业论文 原发性干燥综合症患者血清IL 2014年6月25日 原发性干燥综合症患者血清IL 作者：袁双龙，蒋莉，张晓莉，李舒帆，段宏梅，王晓菲 【关键词】 原发性干燥综合症;，甲状腺功能减退症;白细胞介素 Serum IL21 level in patients with primary Sjgren s syndrome and clinical significance of IL21 [Abstract] AIM: To investigate the relation between the change of semm IL21 level and other laboratory indexes by detecting serum IL21 level from patients with primary Sjgren s syndrome (pSS) and explore the role of IL21 in pSS. METHODS: The level of serum IL21 from 40 pSS patients diagnosed according to 2002 revised international classification criteria for pSS and 30 healthy persons were detected by enzymelinked immunosorbent assay(ELISA) respectively. Meanwhile, FT3，FT4, TSH, TgAb, TPOAb were detected by Immunochemiluminescent technique. Double diffusion method, Westergren and automatic gel method detected antSSA and antSSB antibody, ESR and serum protein electrophoresis respectively. The relationship between serum IL21 level and other clinical symptom of the patients was analyzed. RESULTS: The level of serum IL21 in patients with pSS (1051±335) ng/L was obviously higher than that in healthy control (466±90 ng/L), (P0.05). The levels of serum IL21 in the selfantibody positive group, parotid gland swelling pain group, rash group and incorporating hypothyroidism group were higher than those in their negative control groups, and there were significant differences(P0.05). In addition, The level of serum IL21 level in pSS patients showed positive correlation with yglobulin (r=0.719, P0.05) and ESR level(r=0.745, P0.05). CONCLUSION: The evident increase of serum IL21 level in pSS patients has positive correlation with the levels of yglobulin and ESR, which suggests that IL21 may play a critical role in the pathogenesis of pSS? [Keywords]primary Sjgren s syndrome; hypothyroidism; interleukin21(IL21) ［摘要］目的：通过检测原发性干燥综合症(pSS)患者血清白细胞介 素21 (IL21)的表达水平，探讨其水平变化与pSS患者其他实验室检测指标关系 以及其在pSS发病中的作用。方法：选取符合2002年修订的pSS国际分类标准 的40例初诊pSS患者。采用双抗体夹心ELISA方法检测该组患者及30例正常 对照者血清中IL21的水平。同吋，采用免疫化