氮鸟嘌呤在活化电极上的电化学行为研究福州大学学报.pdf

30 5 () Vol.30 No.5 2002 10 Journal of Fuzhou University (Natural Science) Oct.2002 :1000-2243(2002)05-0614-04 8- , , (, 　350002) :(CV), (LSV)、(NPV), Osteryoung (OS- WV)(CC)8-(8-AG)(AGCE ) .pH=5.3 Britton-Robinson(B-R), 8-AG , (E P ) -7 -4 +0.93 V (vs.Ag AgCl 3 mol L KCl), 8-AG 6.0×10 ～ 1.0×10 mol L , , 6.5×10-8 mol L.8-AG , . 8-AG . :8-;;; :O657.1 :A Study of the voltammetric behaviours of 8-azaguanine at an activated electrode XU Xue-qin, QI Xiu-zhen, CHEN Guo-nan (College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, Fujian 350002, China) Abstract:Voltammetric behaviours of 8-Azaguanine (8-AG),an anticancer drug, have been invest - gated at an activated glassy carbon electrode by cyclic voltammetry, linear sweep voltammetry, normal pulse voltammetry, Osteryoung square wave voltammetry and chronocoulometry .In the Britton-Robin- son (pH=5.3 )buffer solution, one well-defined oxidation peak of 8-AG is obtained, and the peak potential is at +0.93V (vs.Ag AgCl 3 mol L KCl).The peak current is proportional to the concentra- -7 -4 -8 tion of 8-AG over the range of 6.0×10 ～1.0×10 mol L .The dectection limit is 6.5×10 mol L.It is proposed that the number of electrons involved in the oxidation of 8-AG is 4 and the electrode reaction is totally irreversible .The peak current exhibits diffusion characteristics.8-AG was success- fully determined in the spiked human urine samples .The developed method is more sensitive than that