以立体微流道制作双重乳化三相微囊胞.PDFVIP

以立體微流道製作雙重乳化三相微囊胞 Controlled W/O/W Double Emulsification in 3-D PDMS Micro-Channels 本研究利用疏水性高分子材料製作立體微流道，搭配介面活性劑以 限制油相流體在流道表面的濕潤範圍，並維持各相間介面的穩定， 成功產生水油水三相雙重乳化微囊胞。微囊胞的外徑大小、油相球 殼厚度、與水相核心大小可以透過水油水三相流速控制，另外微囊 胞的產生機制與頻率則可藉由流道形狀加以限制。 IOP PUBLISHING JOURNAL OF MICROMECHANICS AND MICROENGINEERING J. Micromech. Microeng. 18 (2008) 065018 (8pp) doi:10.1088/0960-1317/18/6/065018 Controlled double emulsification utilizing 3D PDMS microchannels Fu-Che Chang and Yu-Chuan Su Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan E-mail: ycsu@ess.nthu.edu.tw Received 30 December 2007, in final form 14 April 2008 Published 9 May 2008 Online at stacks.iop.org/JMM/18/065018 Abstract This paper presents a PDMS emulsification device that is capable of generating water-in-oil-in-water double emulsions in a controlled manner. Specially designed 3D microchannels are utilized to steer the independently driven water- and oil-phase flows (especially to restrict the attachment of the middle oil-phase flow on the channel surfaces), and to break the continuous flows into monodisperse double emulsions. In addition to channel geometries and fluid flow rates, surfactants and osmotic agents are employed to facilitate the breakup process and stabilize the resulting emulsion structures. In the prototype demonstration, two-level SU-8 molds were fabricated to duplicate PDMS microstructures, which were surface treated and bonded irreversibly to form 3D microchannels. Throughout the emulsification trials, dripping was intentionally induced to generate monodisperse double emulsions with single or multiple aqueous droplets inside each oil drop. It is found that the overall and core sizes of the resulting double emulsions could be adjusted independently, mainly by varying the outer and inner fluid flow