基于穿心莲内酯、脱水穿心莲内酯、穿琥宁等自乳化制剂影响因素的分析-药剂学专业论文.docxVIP

III III Particle size by visual method and laser particle size determination of scanner are common to compare emulsion appearance. Results showed that the emulsification effect of Andrographolide and Dehydroandrographolide andrographis is superior to Potassium Dehydroandrograpolide Succinate as a whole. This paper studied the influence of formulation of zeta potential, chose the prescription composition under different proportion and determine the emulsion particle size and zeta potential.the results showed that the prescription of drugs (including drugs) have an effect on the zeta potential.Also drug physical and chemical properties influence the zeta potential. The zeta potential and particle size are common to influence the stability of the emulsion. Key Words: SEDDS particle size Andrographolide Dehydroandrographolide zeta potential i i 目录 中文摘要 I ABSTRACT II HYPERLINK \l _bookmark0 前言1 HYPERLINK \l _bookmark1 1 自乳化释药系统（SEDDS）研究现状 1 HYPERLINK \l _bookmark2 SEDDS 定义 1 HYPERLINK \l _bookmark3 SEDDS 特点 1 HYPERLINK \l _bookmark4 SEDDS 处方组成 1 HYPERLINK \l _bookmark5 1.4 SEDDS 应用现状及前景 2 HYPERLINK \l _bookmark6 1.5 存在和亟待解决的问题3 HYPERLINK \l _bookmark7 2 研究的目的、意义3 HYPERLINK \l _bookmark8 正文4 HYPERLINK \l _bookmark8 第一部分 油相对 SEDDS 的影响 4 HYPERLINK \l _bookmark9 1 仪器与试剂4 HYPERLINK \l _bookmark10 2 以穿心莲内酯为模型药物，比较油相的影响4 HYPERLINK \l _bookmark11 2.1 穿心莲内酯溶解度试验4 HYPERLINK \l _bookmark12 2.2 穿心莲内酯 SEDDS 处方的预试筛选 7 HYPERLINK \l _bookmark13 2.3 穿心莲内酯