基于光学低相干干涉的视网膜血液含氧量测量的前期研究-光学工程专业论文.docxVIP

浙江大学碗I．学位硷文 浙江大学碗I．学位硷文 摘要 摘要 双波长光学低相干干涉测量术在这里被建议用来测量人体视网膜血管qai{l| 液的含氧量的分布。 在这篇论文里，首先详尽分析了什么是光学低相干干涉测量术，然后阐述其 刚于测量人体视网膜皿管血液氧气含量的原理。氧基血红素对不同波长的光的吸 收不同，所以取两极端波长——吸收最大和吸收最小波长，可以原则性地估测人 眼视网膜血箭氧气的分布。 通过对简易人眼血管模型—— 内径为200／zm的毛细玻璃管，由Matlab进 行数值模拟血液的吸收情况，进行项日可行性论证，定量给出当血液中氧气含量 由40％提高到60％时，系统灵敏度需要至少达到一70dB。同时通过两个准备实验一 一血液恒温循环实验装置及其在两极值状态下血液的透射率测量实验和牛奶对 白光的吸收实验，来增强实验信心，并进一步确立实验步骤。 然后‘个苹波长光学低相干系统被建立，根据初步测试结果——对大分子物 质牛奶的吸收率测量，来验证数值模拟同时改进实验进程，把理论技术转化为实 际血液测量。 另外，文l|1还详细给出了对测量得到的实际干涉信号的处理过程。 关键字：光学低相干干涉术、氧气含量、氧基血红素、无氧基血红素 浙江大学硕士学位论文Abstract 浙江大学硕士学位论文 Abstract Double wavelength Optical Low—coherent Interferometry(oci)here is proposed to measure the oxygen delivery in human retinal blood vessel． In this report，first detalledly analyze what is Optical Low-coherent Interferometry， then demonstrate the principal of its measurement to oxygen saturation in human retinal blood vessel，The absorption of oxygenerated hemoglobin depends on the wavelength of the incident light，SO here one absorption maximum and one absorption minimum wavelengths are simultaneously used to estimate the oxygen delivery in the human retinal blood vessl． By giving the simple model of human eye blood vessel，a capillary with inner diameter 200tim．Mauab numerical analysis is done to estimate the absorption ofthe blood，which verified the flexibility of this project．And it gives a result when oxygen saturation increases from 40％to 60％，OCI system needs a sensitivity at least一70dB． Meanwhile，two preliminary experiments are done to enhance the confidence of this project and further procedure has been defined based on these results． Then a single wavelength system has been set up with fundamental experiments to prepare the next project step，the transfer ofthe technology to real blood application． This report also gives the detailed signal processing procedure． Keywords： Optical Low-coherent Interferometry， Oxygen Saturation， Oxy—hemoglobin，Deoxy—hemoglobin 浙江大学硕L学位论文