过氧化物还原酶2及其潜在的临床应用价值研究进展-中国现代应用药学.PDF

·综 述 · 过氧化物还原酶 2 及其潜在的临床应用价值研究进展  * 王丽敏，杜诗琦，王佳凤，李博 ，狄斌( 中国药科大学药物分析系，蛋白质化学与结构生物学重点实验室，药物质量与安全预警 教育部重点实验室，南京 210009) 摘要：过氧化物还原酶2(peroxiredoxins ，Prx2)是过氧化物还原酶家族的重要一员，在人体多种组织器官中都有表达，红 细胞内含量极其丰富。Prx2 在清除过氧化物、信号转导、分子伴侣等方面发挥着重要作用。Prx2 结构和表达量的改变与 多种疾病直接相关，是临床诊断及药物开发领域的新关注点。本文从Prx2 的生理功能及其与不同疾病的相关性、不同存 在形式、Prx2 的检测手段3 个方面进行综述，为进一步探究Prx2 与疾病调控机制及其在疾病诊断和潜在临床应用的研究 方面提供参考。 关键词：过氧化物还原酶2 ；生理功能；检测方法；临床应用 中图分类号：R969.3 文献标志码：A 文章编号：1007-7693(2018)10-1573-07 DOI: 10.13748/ki.issn1007-7693.2018.10.032 引用本文：王丽敏, 杜诗琦, 王佳凤, 等. 过氧化物还原酶 2 及其潜在的临床应用价值研究进展[J]. 中国现代应用药学, 2018, 35(10): 1573-1579. Research Progress of Peroxiredoxin 2 and Its Potential in Clinical Applications * WANG Limin, DU Shiqi, WANG Jiafeng, LI Bo , DI Bin(Department of Pharmaceutical Analysis, Key Laboratory on Protein Chemistry and Structural Biology, MOE Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 210009, China) ABSTRACT: Peroxiredoxin 2(Prx2) is an important member of peroxiredoxin family. It is widely distributed in various tissues and organs of human body, especially abundant in erythrocytes. Prx2 can function as a scavenger of peroxide, sensor and transducer of cell signals, molecular chaperone and so on. Changes in the structure and expression of Prx2 are related to many human diseases, consequently making Prx2 a new focus in clinical diagnosis and drug development. This review generally introduced the physiological functions of Prx2 and its relation with different human diseases, as well as detecting techniques of Prx2 in different forms. It aims to study the regulation mechanism of Prx2 and its potential in disease diagnosis and other clinical applications. KEY WORDS: peroxired