结核病动力学模型的稳定性分析基础数学专业论文.docxVIP

中 中 北 大 学 学 位 论 文 第 第 II 页 ABSTRACT Epidemic dynamics is to study disease spread, predict the trends of the disease, ?nd out the key factors in the process of the spread, and prevent the disease by the best methods. TB is a chronic infectious diseases and is one of the oldest diseases in the human recorded. Tuberculosis patients in China accounted for a quarter of the world. The time of individuals to show symptoms after infected with TB bacilli is di?erent. And the treatment time is very di?erent, that is, the disease has acute and chronic two phases. The ability to transmit virus in di?erent stages of infection is di?erent. In this paper, we take into account di?erent factors and create several types of TB model. In chapter 2, a model with fast and slow Tuberculosis is studied, that is, considering the disease has acute and chronic phase of two. First, we discuss the local and global asymptotic stability of disease-free equilibrium and obtain the disease has been eradicated if R0 1; Secondly, we prove the local stability of endemic equilibrium, and use the Lyapunov function obtained su?cient conditions of global stability; Thirdly, we perform the numerical simulation and parameter sensitivity analysis; Finally, according to this theory methods to expand the study of HFMD in China. In chapter 3, we averagely divide the incubation period into n stages and formulate a SLIT TB model with staged progression based on the second chapter. Using the method of next-generation matrix, we obtain the basic reproductive number. The global stability of the equilibrium are proved by constructing appropriate Lyapunov function. In chapter 4, the model also divide the sick period into n stages based on the third chapter. First, we study the basic reproductive number of the model; Second, to prove the existence and uniqueness of the equilibrium by using the matrix theory; Finally, we prove the global stability of the equilibrium by constructing appropriate Lyapunov function. Key w