复配卡拉胶的流变学性质研究Rheologicalpropertiesof-药学学报.PDF

药学学报 Acta Pharmaceutica Sinica 20 18, 53 (8): 1377 1382 ·1377 · 配卡拉胶的流变学性质研究 王文亚, 杨白雪, 宫艳畅, 胡贝贝, 赵雪莉, 李三鸣* (沈阳 科大学 学院, 辽宁 本溪 117004) 摘要: 以黏度为指标考察 -卡拉胶 (kappa carrageenan, KC)-魔芋胶 (konjac gum, KGM) 等6 种复配KC 的 流变学性质。采用旋转法测定黏度; 通过幂律方程 (power-law equation) 对流变曲线进行拟合, 确定流体流型; 以黏度对数对浓度拟合, 考察复配胶浓度对黏度的影响; 根据阿伦尼乌斯 (Arrhenius) 方程, 计算复配胶的黏流 活化能 (E ), 考察温度与黏度的关系; 通过测定复配胶和单体胶的黏度, 考察两者之间的相互作用。结果表明: η 6 种复配胶均为假塑性流体; 不 复配胶性质差异较大, KC-黄原胶 (xanthan gum, XG) 剪切稀化最明显, 假塑性 程度最强, Eη 值最小, 黏度热稳定性最好; KC-透明质酸钠 (sodium hyaluronate, HA-Na) 黏度对浓度的依赖性最 强; 复配胶黏度均大于单体胶的黏度之和, KC 与6 种辅料均具有协同增黏作用。 关键词: -卡拉胶; 辅料; 复配胶; 黏度; 流变学性质 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 18) 08- 1377-06 Rheological properties of compound carrageenan * WANG Wen-ya, YANG Bai-xue, GONG Yan-chang, HU Bei-bei, ZHAO Xue-li, LI San-ming (School of Pharmacy, Shenyang Pharmaceutical University, Benxi 117004, China ) Abstract : The rheological properties of six compound gels that consists of kappa carrageenan (KC) and another excipient such as konj ac gum were explored through comparison of their viscosity measured by the rotation method. The gel fluid type was dependent on the rheological curve fitted by the power-law equation. The effect of concentration on the viscosity of