H型高血压患者血清ADMA和血脂水平变化及其意义.docxVIP

H型高血压患者血清ADMA和血脂水平变 化及其意义 颜培实 大连市中心医院心内一科 摘要： 目的:探讨II型高血压患者血清非对称性二甲基精氨酸（ADMA）、血脂水平的变 化及其临床意义。方法：以2014年3月P15年8月在我院接受治疗的110例高 血压患者为观察对象，并根据其血清同型半胱氨酸（Hey）水平分为H型高血压 组（45例）和非H型高血压组（65例），同时选取50例健康成年人作为对照组。 观察三组血清ADMA、血糖和血脂水平的差异，分析血清ADMA与血糖和血脂水平 的相关性。结果:三组患者ADMA和MBG水平由高到低分别为:11型高血压组、非II 型高血压组和对照组，差异具有统计学意义;三组患者的TC.LDL-C和TG水平由 高到低分别为H型高血压组、非H型高血压组和对照组，HDL-C水平由高到低分 别为对照组、非H型高血压组和H型高血压组，差异具有统计学意义;血清ADMA 水平与MBG、TC、LDL-C和TG水平正相关,与HDL-C水平负相关。结论:H型高 血压患者血清ADMA水平较高，且与患者的血脂和血糖水平显著相关。 关键词： 高血压;同型半胱氨酸;非对称性二甲基精氨酸;血脂;血糖; 作者简介：颜培实，E-mail:wxbu80@aliyun. com 收稿日期：2017-09-02 Changes and significance of serum ADMA and serum lipid levels in patients with type H hypertension Yan Pei-shi Dalian Municipal Central Hospital Affilliated of Dalian Medical University; Abstract： Objective To investigate the changes of serum levels of H and serum levels of non symmetry two (ADMA) in patients with hypertension and its clinical significance. Methods 110 cases of hypertension patients treated in our hospitai from March 2014 to August 2015 were selected as the observation object and according to the level of the serum homocystcinc (Iley) divided H-type hypertension group (45 cases) and non~H type hypertension group (65 cases) , and select the 50 cases of healthy adults as the control group. Three groups of serum ADMA, blood glucose and blood lipid levels were observed, and the correlation between serum ADMA and blood glucose and blood lipid levels were analyzed. Results The levels of ADMA and MBG in the three groups were higher than that in the H group and the control group, the difference was statistically significant; The levels of TC, LDL-C and TG in three groups of patients from high to low are H H type hypertension group emd non hypertension group and control group, HDL~C level from high to low, rcspcctivcly, control group and nonTI type hypertcnsion group and H type hypertension group, the difference has statistical significance; Serum ADMA levels were positively correlated with MBG, TC, LDL-C and