左氧氟沙星联合标准化疗方案治疗肺结核的临床研究.docxVIP

左氧氟沙星联合标准化疗方案治疗肺结核的临床研究 周鸿雁1雷素云2 (1昆明市第三人民医院结核一科云南昆明650041) (2云南省传染病院云南昆明650301) 【摘要】目的：研究左氧氟沙星联合标准化疗方案治疗肺结核的临床效果。 方法：选取我院2012年1月?2014年1月间诊治的肺结核患者70例，将其随机 分为观察组和对照组各35例，对照组患者采用标准化方案治疗，观察组患者在 对照组的基础上加用左氧氟沙星治疗，对比观察两组患者的临床治疗效果及不良 反应情况。结果：观察组患者在治疗后前3个月的临床效果明显优于对照组，差 异具有统计学意义(PV0.05),从第4个月开始，两组差异较小，无统计学意义 (P0.05)；在不良反应方面，观察组的发生率为11.43%,对照组为25.71%, 观察组明显低于对照组，差异具有统计学意义(P0.05)o结论：采用左氧氟沙 星联合标准化疗方案治疗肺结核不仅可以显著改善痰菌阴转、病灶吸收及症状变 化情况，而且还能有效降低不良反应的发生率，值得临床推广使用。 【关键词】左氧氟沙星；标准化疗方案；肺结核；痰菌阴转；病灶吸收 【中图分类号】R453 【文献标识码】A 【文章编号】 2095-1752 (2015) 05-0059-02 Levofloxacin combined sta ndard chemotherapy regime ns in the treatme nt of tuberculosis research Zhou Hongyan. The Third Peoples Hospital in Kunming,Yunnan Provinee, Kunming 650041, China; Lei Suyun. Infectious Diseases Hospital, Yunnan Provinee, Kunming 650301, China [Abstract 】Objective Study of levofloxaci n in combi nation with stan dard chemotherapy regime ns in the treatme nt of tuberculosis ? Methods Selected from January 2012 to January 2012 between the diagnosis and treatment of 70 cases of pulm on ary tuberculosis patie nts, will be ran domly divided into observatio n group and control group, 35 cases in the control group were treated by standardized solution treatment, the observation group of patients in the control group on the basis of treatment with levofloxacin. Results Observation group of patients in the treatme nt of the first 3 mon ths of clin ical effect was better tha n con trol group, differe nee has statistical sign ifica nee (P lt; 0.05), since 4 mon ths, two groups of differenee is small, there is no statistical significanee (P gt; 0.05); In terms of adverse reaction, the incidenee rate of observation group was 11.43%, control group was 25.71%, statistically significant differences in group, significantly lower than the control group (P lt; 0.05). Conclusions Tuberculosis with levofloxacin in combination with standard chemotherapy regimen for not only can significantly improve the symptoms of phlegm germ femini