左氧氟沙星三联疗法治疗消化性溃疡疗效观察.docxVIP

左氧氟沙星三联疗法治疗消化性溃疡疗效 观察 【摘要】目的：探讨左氧氟沙星三联疗法治疗消化 性溃疡的临床效果。方法：选取2012年6月-2013年9月收 治的消化性溃疡患者共96例，随机分为观察组和对照组， 各48例，其中观察组采用左氧氟沙星三联疗法治疗，对照 组则采用阿莫西林三联疗法治疗。结果：观察组患者的总有 效率93. 75% (45/48)优于对照组的81. 25% (39/48),差异 有统计学意义(P0.05)。结论：左氧氟沙星三联疗法治疗消 化性溃疡疗效较阿莫西林三联疗法好，两者不良反应均较 低，从经济费用方面来考虑，左氧氟沙星三联疗法治疗消化 性溃疡较易于推广。 【关键词】左氧氟沙星；三联疗法；消化性溃疡 中图分类号R573. 1文献标识码A文章编号 1674-6805 (2014) 12-0007-02 Clinical Observation of Levofloxacin Triple Therapy in the Treatment of Peptic Ulcer/LIU Ling.//Chinese and Foreign Medical Research, 2014, 12 (12)： 7-8 [Abstract】 Objective： To investigate the clinical curative effect of Levofloxacin triple therapy in the treatment of peptic ulcer?Method： From June 2012 to Sep tember 2013, 96 cases with pep tic ulcer were randomly divided into observation group and control group, each group of 48 cases, the observation group was treated by Levofloxacin triple thera.py and control group with Amoxicillin triple therapy treatment? Result： The total effective rate of observation group was 93. 75% (45/48), the control group was 81.25% ( 39/48 ) , there was statistically significant differenee ( P0.05 ) ?Conelusion : The curative effect of Levofloxacin triple therapy in the treatme nt of pep tic ulcer compared with Amoxicillin triple therapy treatment is better , they also have less adverse reaction, to consider from the aspects of economic cost, Levofloxacin triple therapy treatment of peptic ulcer is relatively easy to popularize? [Key words 】 Levofloxacin； Triple therapy； Pep tic ulcer First-author s address： The People s Hospital of Yingshang County, Yingshang 236200, China 消化性溃疡主要指发生在胃和十二指肠的慢性溃疡，即 胃溃疡和十二指肠溃疡。因溃疡形成与胃酸和胃蛋门酶的消化作用有关而得名。溃疡的黏膜缺损超过黏膜肌层，不同于 糜烂（糜烂是黏膜缺损未超过黏膜肌层）[l]o多数学者认 为，溃疡的产生是因胃酸和胃蛋白酶分泌增多，各种因素致 局部黏膜抵抗力降低，黏膜屏障被破坏，从而形成自家消化, 对胃肠黏膜和肌层产生腐蚀而致溃疡。从溃疡病变部位来 看，胃溃疡多发生在胃小弯和幽门部，以后壁为多；十二指 肠溃疡多发生在十二指肠球部，以前壁为多（约50%）o从形 态上看，溃疡多呈圆形、椭圆形，少数可呈不规则形、线形 和霜斑样等，其直径一般小于2 和霜斑样等，其直径一般小于2?3 cm, 少数胃溃疡可大至 4?7 cm, 85%的十二指肠球部溃疡不超过1 cm。溃疡一般深 达黏膜下肌层，边缘整齐，略高于黏膜，有炎症、水肿和纤 维组织增生。溃疡基底部洁净，上覆盖灰白，其下层可见肉 芽组织及