过度运动中肌腱细胞增殖、凋亡与相关生长因子蛋白表达特征的研究-体育学专业论文.docxVIP

过度运动中肌腱细胞增殖、凋亡与相关生长因子蛋白表达特征的研究 过度运动中肌腱细胞增殖、凋亡与相关生长因子蛋白表达特征的研究 万方数据 万方数据 at 4 weeks value (P0.01), and then decreased at 8 weeks. The expression of BMP12 protein increased gradually, reached a peak at 6 weeks (P0.05), and declined slightly at 8 weeks. Conclusion: Downhill running could cause degenerative changes in rat biceps brachii tendon intertubercular sulcus parts. Excessive Apoptosis and insufficient proliferation of tenocytes is an important pathological phenomenon of tendon degeneration by overused-induced, can lead to the decrease in the number of tenocytes, weakening the tendon repair ability. During overuse process, long-term abnormal expression of growth factors was an important pathological chang of tendon degeneration. The growth factors expression were different between biceps brachii tendon intertubercular sulcus parts and whole tendon. Not all growth factors protein expression would be changed. Key Words：overuse；tendon；degeneration；growth factor 论文随机验证编号：BT6571243728 VI 目录 HYPERLINK \l _bookmark0 缩略语说明 - 4 - HYPERLINK \l _bookmark1 1. 前言 - 7 - HYPERLINK \l _bookmark2 2. 综述 - 8 - HYPERLINK \l _bookmark3 2.1 肌腱 - 8 - HYPERLINK \l _bookmark4 2.2 运动与肌腱退行性变 - 10 - HYPERLINK \l _bookmark5 2.2.1 运动对肌腱的影响 - 10 - HYPERLINK \l _bookmark6 2.2.2 肌腱退行性变病理特征 - 11 - HYPERLINK \l _bookmark7 2.2.3 肌腱退行性变动物模型 - 12 - HYPERLINK \l _bookmark8 2.3 生长因子与肌腱损伤、修复 - 13 - HYPERLINK \l _bookmark9 2.3.1 胰岛素样生长因子 1 - 15 - HYPERLINK \l _bookmark10 2.3.2 转化生长因子 β1 - 18 - HYPERLINK \l _bookmark11 2.3.3 碱性成纤维细胞生长因子 - 21 - HYPERLINK \l _bookmark12 2.3.4 骨形态发生蛋白 12 - 25 - HYPERLINK \l _bookmark13 2.3.5 其他生长因子 - 28 - HYPERLINK \l _bookmark14 3. 研究材料与方法 - 29 - HYPERLINK \l _bookmark15 3.1 肱二头肌肌腱过度运动模型 - 29 - HYPERLINK \l _bookmark16 3.1.1 实验对象 - 29 - HYPERLINK \l _bookmark17 3.1.2 运动方案 - 29 - HYPERLINK \l _bookmark18 3.2 取材 - 30 - HYPERLINK \l _bookmark19 3.2.1 取材时机 - 30 - HYPERLINK \l _bookmark20 3.2.2 取材步骤 - 30 - HYPERLINK \l _bookmark21 3.3 切片与染色 - 31 -