米库氯铵用于无抽搐电休克治疗的临床研究.docxVIP

米库氯鞍用于无抽搐电休克治疗的临床研究 孙忠锋(通讯作者) 王翠芳 吴其瑾 勇梅杰 于海洲 王昭君 (山东省威海市经济技术开发区医院麻醉科 山东威海264205) 【摘要】目的 观察米库氯鞍在无抽搐电休克治疗时的可行性及安全性。方法 选择ASA分级1?11级，精神心理科行MECT治疗的患者36例，按要求分为琥珀 胆碱组(S组,n=18)和米库氯镀组(M组,n=18)o麻醉方法S组丙泊酚1.5-2mg/kg 琥珀胆碱 0.8-1.0mg/kg;M 组：丙泊酚 1.5-2mg/kg^ 米库氯0.08-0.12mg/kg,两组 均用麻醉机面罩加压呼吸，S组在用药后1.5-2.0min实施电刺激治疗，M组在用 药后2.0-2.5min实施电刺激治疗。观察并记录患者在用药前(TO)、推药后(T1)、 电刺激时(T2)和电刺激后2分钟(T3)时的SBP、DBP、HR。记录电刺激发作 时间、呼吸恢复时间、意识恢复时间。结果 与T0时比较，两组T2时HR均明 显升高(plt;0?01) /旦以S组升高明显，组间比较plt;0.01, S组T2时的SBP、 DBP与T0时比较明显升高(plt;0.01),但M组在T2时SBP、DBP均低于T0, 与S组组间比较plt;0.01o结论 米库氯鞍在无抽搐电休克治疗时血流动力学比 较稳定，是替代琥珀酰胆碱的比较理想的非去极化肌松药，可安全用于无抽搐电 休克治疗。 【关键词】亚剂量 米库氯镀 无抽搐电休克 【中图分类号】R45 【文献标识码】A 【文章编号】2095-1752 (2013) 14-0139-02 The clinical research of Mivacurium for no electric convulsive therapy Sun zhong?feng, wang cui-fang. Wei hai jing qu hospital Department of anesthesiology weihai 264205 . 【Abstract】 Objective to observe the feasibility and safety of Mivacurium for no electric convulsive therapy. Method 36 patients(ASA I - Il) received MECT treatment in psychological department were divided into 2 groups, succinyIcholine (group S, n二 18) and Micoud chloramines(group M, n二 18). Anaesthesias methods: group S received propofol 1.5-2mg/kg^ succinyIcholine 0.8-1.0mg/kg, group M: propofol 1.5-2mg/kg ?Both received Anesthesia mask pressure breathing, for group S, the interval time between electrical stimulation is 1.5-2.0min, whereas group M is 2.0-2.5mi n. observe a nd record SBP、DBP、HR at T0 Tl^ T2 a nd T3. Record time of Electrical stimulation attack Breathing recovery and Consciousness recovery. Result compared with TO, HR in creased sign ifica ntl% however, group S raised eve n more rapidly, (plt;O.Ol) . for group S, compared with TO, SBP and DBP at T2 increased significantly (plt;0.01)? whereas, SBP and DBP at T2 were lower than these at TO, (plt;O.Ol) conclusion The mivacurium is more stable in the aspect of Hemodynamic for no electric convulsive therapy,which is the ideal non-depolarizing muscle relaxa nts for alte