巩膜镜控制干眼症(英文).pdfVIP

Biology of Blood and Marrow Transplantation 13:1016-1021 (2007) 2007 American Society for Blood and Marrow Transplantation 1083-8791/07/1309-0001$32.00/0 doi:10.1016/j.bbmt.2007.05.006 Use of Fluid-Ventilated, Gas-Permeable Scleral Lens for Management of Severe Keratoconjunctivitis Sicca Secondary to Chronic Graft-versus-Host Disease Kikuchi Takahide,1 Pablo M. Parker,2 Michael Wu,3 William Y.K. Hwang,4 Paul A. Carpenter,1,3 Carina Moravec,1 Barbara Stehr,2 Paul J. Martin,1,3 Perry Rosenthal,5 Stephen J. Forman,2 Mary E.D. Flowers 1,3 1Fred Hutchinson Cancer Research Center, 2Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, 3University of Washington, Seattle, Washington; 4Singapore General Hospital, SingHealth, Singapore; and 5Harvard Medical School and Boston Foundation for Sight, Boston, Massachusetts Correspondence and reprint requests: Mary E.D. Flowers, MD, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D5-290, Seattle, WA 98109 (e-mail: mflowers@fhcrc.org). Received March 21, 2007; accepted May 7, 2007 ABSTRACT Keratoconjunctivitis sicca (KCS) occurs in 40%-60% of patients with chronic graft-versus-host-disease (cGVHD) after allogeneic hematopoietic cell transplantation. Although immunosuppressive therapy is the primary treatment of chronic GVHD, ocular symptoms require measures to improve ocular lubrication, decrease inflammation, and maintain mucosal integrity. The liquid corneal bandage provided by a fluid- ventilated, gas-permeable scleral lens (SL) has been effective in mitigating symptoms and resurfacing corneal erosions in patients with