肝动脉化疗栓塞在预防原发性肝癌术后复发中的作用.docxVIP

肝动脉化疗栓塞在预防原发性肝癌术后复发中的作用 张岳林孙军辉 聂春晖 陈黎明 章丽霞 蔡丽霞 何健娣 王伟林 郑树 森（通讯作者）（浙江大学医学院附属第一医院肝胆胰外科及器官移植重点实验 室浙江杭州310003） 【摘要】目的 探讨肝动脉化疗栓塞术（TACE）对原发性肝癌（HCC）根治术后 抗复发作用。方法 回顾性收集2008年1月至2009年7月间HCC根治术后未 接受预防性TACE的患者40例（对照组）和术后接受一次预防性TACE的患者27 例（治疗组），治疗组患者在术后1?2月给予一次预防性TACEo全部病例在根治 术后随访36-40个月，对比分析两组间的累计复发率。结果HCC根治术后，对 照组1, 2, 3年累计复发率分别为57.5%, 65.0%, 67.5%；治疗组1, 2, 3年累 计复发率分别为29.6%, 33.3%, 33.3%。统计学分析治疗组1、2、3年复发率均 明显低于对照组（P二0.019、P=0.012 P二0.008）。治疗组TACE术后反应较轻，患 者均可耐受，未出现严重并发症。结论HCC根治术后给予一次预防性TACE在 临床应用上是可行、安全、有效的，可明显降低术后复发率。 【关键词】原发性肝癌化疗栓塞肿瘤复发根治性切除 【中图分类号】R73-3【文献标识码】A【文章编号】2095-1752 （2013 ） 03-0132-03 Role of Transcatheter Arterial Chemoembolization on Preventing Recurre nee following Radical Resection for Hepatocellular Carci noma Yue-lin ZHANG, Jun-hui SUN, Chun-hui NIE, Li-ming CHEN, Li-xia CAI, Jian-di HE, Li-xia ZHANG, Wei-lin WANG, Shu-sen ZHENG Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery First Affiliated Hospital, School of Medicine, Zhejiang University, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation, Zhejiang Provinee, Hangzhou 310003,China 【Abstract] Objective To explore the clinical efficacy of transcatheter arterial chemoembolization (1ACE) on preventing postoperative recurrenee of hepatocelular carcinoma. Methods A total of consecutive 67 postopetative patie nts with hepatocellular carci no ma(HCC) from Janu ary 2008 to July 2009 were collected retrospectively.The patients were divided into two groups according receiving TACE or not:the control group (n二40) with operation only and the study group (n二 27) with receivi ng one prophylactic TACE at 1-2 mon ths after operation. All cases were followed up for 36 to 40 mon ths after surgery. The rates of cumulative recurrenee between two groups was compared. Results The 1-, 2? and 3-year cumulative recurrent rates in control group were 57.5%、65.0% 67.5% respectively, while as were29.6% , 33.3% , 33.3% in the study group,respe