早产儿呼吸暂停与高胆红素血症的关系-南方医科大学学报.PDF

2010;30(9) 南方医科大学学报(JSouthMedUniv) 窑2139 窑 早产儿呼吸暂停与高胆红素血症的关系 刘兰梅袁洪 虹袁李立新袁叶丽霞袁黄健斌袁李志涛袁梁颖娜袁蹇 涵渊广州市白云区妇幼保健院儿科袁广东 广州 510400冤 摘要院目的 探讨高胆红素血症对早产儿呼吸暂停的影响遥 方法 对体质量1500g伴呼吸暂停的早产儿进行治疗前后 心率尧血清胆红素水平尧血气分析袁并与足月产儿对照曰对出生第 1天和第3天尧体质量1500g有或无呼吸暂停的早产 儿进行血清胆红素水平尧血气分析比较遥 结 体质量1500g伴呼吸暂停的早产儿和足月儿中袁不同程度血间接胆红 素增高者分别占92.5%和70.0%遥 在体质量1500g极低体重早产儿中袁出生第1天有呼吸暂停者袁血间接胆红素水平 明显比无明显呼吸暂停的高遥常规治疗后第3天袁随胆红素水平相对降低袁呼吸暂停明显改善遥结论 血清胆红素水平 增高是早产儿呼吸暂停的原因之一袁降胆防治有利于改善早产儿呼吸暂停遥 关键词院早产儿曰高胆红素血症曰呼吸暂停 中图分类号院R722.17 文献标识码院A 文章编号院1673-4254渊2010冤09-2139-03 Relationshipbetweenapneaandhyperbilirubinemiainprematureinfants LIULan-mei,HONGHong,LILi-xin,YELi-xia,HUANGJian-bin,LIZhi-tao,LIANGYing-na,JIANHan DepartmentofPediatrics,MaternalandChildHealthHospitalinBaiyunDistrict,Guangzhou510400,China Abstract: Objective To explorethe association between hyperbilirubinemiaand apnea in premature infants. Methods Prematureinfantswithapneaandbirthweight1500gweretestedfortheheartrate, serumlevelofbilirubin, saturationof bloodoxygen(SO )andpartialpressureofoxygen(PO)beforeandaftertreatment,withterminfantsservingasthecontrol.A 2 2 comparativeanalysesoftheserumlevelofbilirubin, SO andPO werecarriedoutintheprematureinfantswithbirthweight 2 2 1500gsufferingapneicsyndromeornotonthefirstandthirddaysafterbirth. Results Oftheprematureandterminfants with apnea and birth weight 1500 g, 92.5% and 70.00% showed increased serum level of indirect bilirubin (IBIL), respectively. Theinfantswithbirthweight1500gwhopresentedthesyndromeofapneaonthefirstdayafterbirthhad significantlyhigher levelsofIBILthan thosewithout an apparentsyndrome of apnea. A three-dayconventional therapy resultedinanobviousimprovementofapneicsyndromeandloweredbilirubinlevel. ConclusionIncreasedbilirubinlevelcan be one of the reas