基质金属蛋白酶—9基因多态性与急性脑梗死的相关性研究-神经病学专业论文.docxVIP

浙江大学硕上学位论文 浙江大学硕上学位论文 摘要 组为10．384-4．68ng／mL，较对照组显著增高(P=0．000)。其MMP．9水平与患者 的神经功能缺损程度评分(NIHSS)无明显关系，相关系数为r=0．186(P=0．257)。 脑梗死组CT基因型患者外周血MMP．9水平为98．394-68．82ng／mL。而CC基因型 患者外周血MMP一9水平为139．264-103．38ng／mL，两者相比差异无显著意义 (P=o．458)。脑梗死组CT+TT基因型频率15．4％，对照组为13．3％，两者比较差 异无统计学意义(x2=0．09，P=0．764)，T等位基因频率在脑梗死组为7．7％，对照组 为7．8％，两者比较差异也无统计学意义(x2=o．001，P=0．981)。 四、结论： 脑梗死患者48小时内外周血MMP．9水平较对照组明显升高(P=O．ooo)，其 血清MMP．9水平与NIHSS无关(r=O．186，P=0．257)。脑梗死组CC基因型和 CT基因型血清MMP．9水平比较差异无显著性(P=O．458)。 脑梗死组CT+TT基 因型频率与对照组比较差异无统计学意义(X2=0．09，P=0．764)，脑梗死组T等位基 因频率与对照组比较差异也无统计学意义(X2=0．001，P=0．981)。本研究认为 MMP．9基因启动子一1562位点的多态性与MMP．9基因表达和脑梗死没有明确的 关系。MMP．9基因启动子C．1562T的多态性与缺血性脑血管疾病的关系有待进一 步研究。 关键词： 基质金属蛋白酶一9 基因多态性 脑梗死 2 浙江大学硕E学位论文 浙江大学硕E学位论文 摘要 Study on the relation between matrix metalloproteinase一9 polymorphism(C一1562T)and acute cerebral infarction In Han Population of China department ofneurology Zhejiang university postgraduate Zhou Yuanlin Supervisor Ding Meiping Abstract Cerebral infarction(CI)refers to a disease of ischemia that causes necrosis and softening of the brain tissue and the patients often have corresponding nervous system symptoms such as hemiplegia and aphasia．The persons who suffer from the disease are usually more than 50 years old with cerebral arteriosclerosis．It has become a great danger to human health with it’S hi曲morbidity and mortality as a kind of multifactor disease that includes environmental and genetic factors．In recent years，researches have been made in the new field on the potential influence of gene polymorphism and gene mutation on cerebral infarction．It is believd that gene structure and expression abnormality,including mutation，shifting，inserting and lacking of the gene may be the basic reasons for cerebral infarction．This paper 塑塑堕壁垡堕塑要 塑塑堕壁垡堕 塑要 makes a research on the relationship between MMP．9(Matnix metalloproteinase。9)and cerebral infarction，especially on genetic polymorphism in MMP-9 promoter(C．1 562T)to make clear whether it is a dangerous genetic factor of ce