急性胰腺炎患者早期脂质运载蛋白2的变化及对预后判断的意义研究-内科学专业论文.docxVIP

PAGE PAGE 3 重指数没有统计学差异， P0.05o 4、N 组 LCN2 (83.16土28.47g/L) 小于 M 组( 106.36土 17.84Jlg/L， P0.05) 和 S 组 (658.96土280.60Jlg/L， P0.05)o M 组和 S 组发病 24h LCN2 有统计学差异， P0.05 ，发病 48h LCN2 也有统计学差异， P0.05o M 组 (5.32土2.72mg/L)与 S 组 (6.38土2.21mg/L) 发病 24h 的 CRP 没有明显差异， P0.05。发病48h ， M 组 (25.27:!:38.85 ，mg/L) 与 S 组 (58.85士33.19，mg/L) 有差异， 但不明显， P=0.0480.05o 5、M 组发病 24h 的 LCN2 和 CRP 与发病 48h 的 LCN2 和 CRP 相比均没有差异， P0.05oS 组发病 24h 的 LCN2 与发病 48h 的 LCN2 相比没有差异， P0.05 ，而CRP 有差异， P0.05o 结论: 1、肥胖是急性膜腺炎的易发因素，可能是预后不良的指标之 一。 2、LCN2 可作为判断急性腆腺炎预后的指标。 关键词:重型急性膜腺炎;轻型急性膜腺炎:肥胖:人脂质运载蛋白 …2; C叩反应蛋白:预眉 Prognostic value of early changes of Iipocalin -2 in patients with acute pancreatitis Abstract: objective: To investigate whether lipocalin -2 can detennine prognosis of acute pancreatitis by comparing the levels of lipocalin -2 (LCN2) in peripheral blood between nonnal healthy adult ， mild acute pancreatitis patients ，sev町e acute pancreatitis patients . Methods: 1，44 patients whom the onset of acute pancreatitis within 24 hours consisted of a case group according to the diagnostic criteria for clinical guidelines of acute pancreatitis of china in 2004. The cωe group divided into mild group (M group) and sever group (S group ) according to disease process of the patients . 32 cases of healthy adults randomly selected as nonnal control group (N group). 2，the gender，age and the degree of obesity (indicated by body mass index) were recorded in control group. APACHE 11 score was executed in case group within 24 hours and 24h to 48h after admission . The blood samples within 24h and 48h after the onset were received in the case group and in the control group. Serum specimens centrifuged 仕Om blood samples，were stored in -70C. 丁he C-reactive protein of the same patient also was detected at the same time segment. 3，The Enzyme-linked immunosorbent assay was used to test the value of lipocalin ♂of serum specimens received at di旺erent times both in the control group and the case