急性脑梗死患者血小板-白细胞聚集体的检测及汉维民族间的比较-内科学专业论文.docxVIP

— — PAGE 1— 摘 要 急性脑梗死患者血小板-白细胞聚集体的检测 及汉维民族间的比较 研究生：杜朴 导师：张小宁教授 摘 要 目的：探讨血小板-白细胞聚集体(PLA)的检测对维汉两民族中急性脑梗死(ACI) 患者的意义，及其与血浆C反应蛋白(CRP）、脑梗死体积的关系。方法：用双标记 流式细胞术检测62例ACI患者和40例对照组的PLA、血小板-中性细胞聚集体(PNA)、 血小板-淋巴细胞聚集体(PLyA)、血小板-单核细胞聚集体(PMA)，用免疫散射比浊法 检测C-反应蛋白(CRP)，并记录头部CT所示梗死体积。结果：①汉族和维族ACI患者 PLA、PNA、PLyA与相应民族对照组无统计学差异。汉族与维族ACI患者PMA治疗 前（11.97±2.15%，11.81±2.35%）高于治疗后（7.81±1.79%，7.72±1.86%），且治疗 后高于对照组（6.68±1.17%，6.73±1.06%），P均0.01；且两民族ACI患者治疗前后 PMA无统计学差异；②治疗前PMA水平与CRP呈正相关，(r = 0.718，P0.05)；③不 同梗死体积患者的PMA水平无统计学差异。结论：PMA是反映ACI患者血小板活化 的良好指标，并能反映机体炎症水平，在ACI的发生和发展过程中起着重要作用。 关键词：脑梗死；血小板-白细胞聚集体；血小板活化 新疆医科大学医学硕士学位论文 Clinical significance of platelet-leukocyte aggregates in patients with acute cerebral infarction and comparison between Uygur Patients and Han Patients Postgraduate: DU Pu Supervisor: Prof. ZHANG Xiao-ning Abstract Objective:To explore the clinical significance of leukocyte-platelet aggregates (PLA) in patients with acute cerebral infarction and the difference of PLA between Uygur Patients and Han Patients. Methods:62 patients with acute cerebral infarction and 40 controls. The levels of PLA, platelet-neutrophil aggregates(PNA),platelet-lymphocyte aggregates (PLyA),platelet-monocyte aggregate (PMA) and C-reactive protein(CRP) were measured. Results:There were no differences in the percentages of PLA, PNA and PLyA between patients and controls. However, in both Uygur and Han Patients before treatment, the percentage of PMA (11.97±2.15% ， 11.81±2.35%) was significantly increased compared with that after treatment (7.81±1.79%，7.72±1.86% , P 0. 01) which was significantly higher than that of controls (6.68±1.17%，6.73±1.06% , P 0. 01). The level of PMA was positively correlated with that of serum CRP in cerebral infarction patients before treatment (r = 0.718, P 0. 05). Conclusion:The levels of PMA in patients with cerebral infarction may be regarded as a good marker of platelet activation and reflect the activity of inflammatory responses in the patients. Key words: