恢复期肺栓塞患者运动耐力及通气有效性的随访研究-内科学(呼吸系病)专业论文.docxVIP

恢复期肺栓塞患者运动耐力及通气有效性的随访研究英文摘要 恢复期肺栓塞患者运动耐力及通气有效性的随访研究 英文摘要 英文摘要恢复期肺栓塞患者运动耐力及通气有效性的随访研究 英文摘要 恢复期肺栓塞患者运动耐力及通气有效性的随访研究 PAGE PAGE III IV IV Follow-up study on the exercise capacity and ventilatory efficiency in the patients with pulmonary thromboembolism Abstract [Objective] To study the changes of Ventilatory efficiency and exercise capacity during Cardiopulmonary Exercise Testing (CPET) in patients with pulmonary thromboembolism after anticoagulant therapy from 2 weeks to 6 months. [Methods] Cardiopulmonary exercise testing,pulmonary function test and arterial blood gas analysis was performed in 30 patients with PTE after anticoagulant therapy 2 weeks (early phase) and 6 months after (late phase). In addition ,another 30 healthy volunteers (the control group) were given the same tests. [Results] (1) There were no significant differences in age[(57.47± 11.33)vs.( 60.27±6.23)years], gender and BMI[(24.02±2.61) vs.(23.85± 2.94)kg/m2,P0.05]. The resting parameters from ABG and PFT ， such as PaO2, FVC%pred, FEV1%pred, MVV%pred, TLC%pred, DLCO%pred in the PTE group after treatment of 2 weeks and 6 months both were significantly lower than those of the control group（P0.05），thus, P(A-a)O2 was higher than that in the control group（P0.01）. After treatment for 6 months , FVC% pred improved obviously in the PTE group （P0.01）, other resting parameters, such as PaO2, FEV1% pred, MVV%pred, TLC%pred, DLCO%pred had no significant statistical differences than the early phase（P0.05）. In the two groups of PTE patients, AT, AT-VO2% pred, peak LOAD, peakLOAD%pred, peak VO2, peakVO2%pred were significantly lower than in the control group（P0.01）. While other parameters such as lowest VE/VCO2, lowestVE/VCO2%pred, AT-VE/VCO2, AT-VE/VCO2%pred, VE/VCO2slope, VE/VCO2slope%pred were significantly higher than in the control group（P0.001）. After treatment for 6 months, peak LOAD, peak LOAD%pred, peak VO2, peak VO2%pred increased significantly in the PTE group (P 0.01), in addition, lowe