活血化瘀利水中药治疗老年ISH临床疗效观察中医内科学专业论文.docxVIP

PAGE PAGE 4 献 ·························································································· ····34 附 录 37 综 述 ·························································································· ···········39 致 谢 ·························································································· ···········49 攻 读 学 位 期 间 发 表 的 学 术 论 文 目 录 ·········································50 广 西 中 医 学 院 研 究 生 学 位 论 文 作 者 声 明 ·······························51 个 人 简 历 ······················································································52 中 文 摘 要 目 的：本研究在论证老年高血压中医基本病机的基础上，探讨活 血化瘀利水中药复方协同治疗老年单纯收缩期（ISH）高血压的临床疗效 及作用机制。 方 法：将 60 例老年高血压患者（中医诊断为眩晕-血瘀证）随机 分为活血化瘀利水中药复方治疗组 30 例，对照组 30 例。治疗组与对照 组均给予硝苯地平缓释片，治疗组在对照组基础上加用活血化瘀利水中 药复方。观察两组治疗前后降压疗效、临床症状和相关实验室指标的变 化。 结 果：协同降压疗效判定:治疗组显效率为 56.67%，对照组为 36.67%，治疗组优于对照组（P＜0.05）；在减少老年高血压晨峰发作次 数、干预老年 ISH 晨峰变异方面治疗组明显优于对照组（P＜0.05）；在 调节血脂方面,治疗组治疗后 TC、TG、LDL-C、HDL-C 较治疗前明显改善 （P＜0.05），对照组无明显变化（P＞0.05）；在干预血管内皮炎性反应 方面治疗组优于对照组（P＜0.05）。治疗期间颈动脉内膜中层厚度基本 稳定（P＞0.05）。 结 论：通过该研究证明活血化瘀利水中药复方对老年高血压患者 具有协同降压作用，并可通过干预 PP、BPV 及内皮炎性反应，调节血脂 延缓 AS 进程，有效改善老年高血压患者全身症状，干预老年 ISH 心血管 危险。 关键词： 单纯收缩期高血压（ISH）；老年人；活血化瘀利水中药复方 The clinical study on treatment to Isolated Systolic Hypertension in elderly by Huoxuehuayulishuifufang ABSTRACT Objective: To observe the clinical effects of the mixture of HuoXueHuaYuLiShuiFuFang (HXHYLS) in treating Isolated Systolic Hypertension in elderly. Methods: These sixty cases were randomly divided into the treatment group(30 cases) and the control group(30 cases). Patients in the control group were given convensional weastern medical therapy, and patients in the treatment group were given HXHYLS and weastern medical therapy. The changes of clinical symptoms and laboratory indexes in all the patients were observd before and after treatment. Result: After treatment with different management, the excellence effective rate of Antihypertensive effect is 56.67% which given HXHYLS and weastern me