活血化瘀方对动脉粥样硬化心血瘀证干预作用的实验研究-中医诊断学专业论文.docxVIP

值，升高血清apoA。、apoA。／apoB。比值；亦能降低家兔全血粘度(低切、 值，升高血清apoA。、apoA。／apoB。比值；亦能降低家兔全血粘度(低切、 高切)、红细胞比容：升高血清SOD活性；缩减主动脉斑块面积和灰度， 亦能抑制AS病理形态改变。④丹参饮能降低家兔血清TC、LDL—C含量； 亦能降低家兔全血粘度(低切)、红细胞比容；明显升高血清SOD活性； 缩减主动脉癍块面积，抑制AS病理形态改变。⑤失笑散能降低家兔血 清TC、LDL—c、TG含量；亦能降低家兔红细胞比容；缩减主动脉斑块面 积，抑制AS病理形态改变。⑥桃红四物汤能降低家兔血清TG含量；能 升高血清apoA。含量；能降低家兔全血粘度(低切)；无明显抑制As病 变的作用。 结论：血脂增高，血液流变学异常改变，自由基代谢异常，这可能 是(As)心血瘀证形成的内在病理机制。五首活血化瘀代表方均具有不同 程度地调节降脂、载脂蛋白代谢，改善血液流变状态，提高SOD活性、 降低MDA含量，抑制高脂喂饲家兔动脉粥样硬化形成的作用。其中，血 府逐瘀汤优于活络效灵丹、丹参饮、失笑散，桃红四物汤疗效最差。为 临床辨证论治提供了理论和实验依据。 关键词：活血化瘀方；动脉粥样硬化；心血瘀证；血脂；载脂蛋白； 血液流变学；病理形态学 Experimental Experimental Study of Intervenient Effects the Recipes for Promoting Blood Circulation and Removing Blood Stasis on Heart Blood Stasis Syndrome in Atheriosclerosis Postgraduate：Luo Yaoyue Tutor：Zhou Xiaoqing fHunan College of Traditional Chinese Medicine，Changsha，410007) ABSTRCT Objectve：To investigate intervenient effects of five recipes for promoting blood circulation and removing blood stasis on the syndrome of heart blood stasis of atheriosclerosis(AS)． Methods：56 male white big ear rabbits were randomly divided into 7 groups normal group，model group，Dan shen yin(DSY)group，Xuefu zhuyu tong (XFZYT)group，Shi xiao san(SXS)group，Huo luo xiao lin dan(HLXLD) group and Tao hong si wu tong(THSwT、group．Besides the normal group．each of the rabbits was fed high cholesterol diet for 63 days·The blood was drawn from the central ear artery to determine serum lipid，apoprotein，hemorheoloy，superoxide dismutase(SOD)actiVity and the level of malondialdehyde(MDA),The samples of arteries and hearts were taken for the histopathological changes of the aorta and coronary artery analysis Results：Compared Results：Compared with the nomal group，the model group’S serum lipid and apoproteinBloo(apoBloo)，hemorheoloy and the contents of MDA increased； the activity of SOD decreased；a lot of lipid foam cells migrated to the regions of intima and smooth muscle cells(SMC)which associated injuries of internal elastic lamina．Com