活血化瘀类中成药治疗冠心病不稳定型心绞痛不同中医证型疗效对比性分析-中西医结合临床专业论文.docxVIP

成都中医药大学硕士学位论文 成都中医药大学硕士学位论文 PAGE PAGE 3 中文摘要 目的：采用前瞻性研究的方式评价活血化瘀类中成药丹红注射液、红花注射液、 疏血通注射液对冠心病不稳定型心绞痛不同中医证型的临床疗效。 方法：从成都中医药大学附属医院心血管内科住院部收集符合冠心病不稳定型心 绞痛诊断标准的患者，按前瞻性的随机设计。把符合纳入标准病例共 92 例分为 3 组：西医常规治疗加丹红注射液 32 例（A 组）；加红花注射液 30 例（B 组）；加疏 血通注射液 30 例（C 组）。疗程 2 周，观察 3 组及每组各中医证型治疗前后各症状 积分及相关检查变化情况。 结果：1. 3 组对心绞痛各疗效判定标准进行对比，3 组间显效率及总体有效率均 无统计学意义（P＞0.05）； 2.A 组、C 组心血瘀阻证与痰浊闭阻证、气滞心胸证心绞痛改善疗效显效率及总体 有效率对比均有统计学意义，P 值均＜0.05，痰浊闭阻证与气滞心胸证对比无统计 学意义，P＞0.05； 3. B 组 C 组心血瘀阻证与痰浊闭阻证、气滞心胸证间中医症候疗效显效率及总体 有效率对比有统计学意义（P＜0.05），痰浊闭阻证与气滞心胸证间对比无统计学 意义，P＞0.05； 4.3 组各中医证型间心电图改善疗效及心肌损伤标志物疗效改善对比均无统计学 意义，P＞0.05。 结论 ：1.丹红注射液、红花注射液及疏血通注射液治疗 UAP 疗效相当； .丹红注射液、疏血通注射液对 UAP 心血瘀阻证心绞痛改善疗效优于痰浊闭 阻证及气滞心胸证； .红花注射液、疏血通注射液对 UAP 心血瘀阻证中医症候疗效优于痰浊闭阻 证及气滞心胸证； .丹红注射液、红花注射液、疏血通注射液对 UAP 心血瘀阻证、痰浊闭阻证、 气滞心胸证心电图改善疗效及心肌损伤标志物改善疗效相当。 5. 综上结果提示，活血化瘀类中成药治疗 UAP 心血瘀阻证部分疗效判定标准 优于痰浊闭阻证及气滞心胸证。 关键词：活血化瘀类中成药 冠心病不稳定型心绞痛 不同中医证型 Abstract Objective: To evaluate the therapeutic effect of blood-activating and stasis-dissolving Traditional Chinese patent drugs, as Danhong Injection, Honghua Injection, Shuxuetong Injection, for unstable angina pectoris of coronary artery disease with different syndrome differentiation in a prospective study. Method: Patients were recruited from inpatient department of Cardiology, Teaching Hospital of Chengdu University of TCM. 92 patients meeting the inclusion were randomized allocated into 3 groups, respectively conventional treatment with Danhong Injection (n=32), conventional treatment with honghua Injection (n=30), conventional treatment with Shuxuetong Injection (n=30). The treatment session was 2 weeks, and the outcome assessments were symptom index and responding biomedical results. Results: 1 there was no difference between groups in improvement rat and over responding rat, which indicated all the 3 groups were effective. For A and C groups, significant differences was detected between syndrome of blood-stasis and turbid-phlegm-obstruction or qi-stagnation, in improvement rat and over responding rat