黄波罗花化学成分及其生物活性研究-药物化学专业毕业论文.docxVIP

第二军医大学硕士学位论文Abstract 第二军医大学硕士学位论文 Abstract Incarvillea lutea a member of the genus Incarvillea(Bignoniaceae)，is mainly distributed in Yunnan and Sichuan provinces．It iS often treated as omamental plant because of its beautiful flowers．Recently,the lncarvillea species have been found to be a rich source of actinidine—type monoterpenoid alkaloids，and possess significant antinociceptive activity．It was also reported that some monoterpenoid alkaloids and iridoids have been isolated from上delavayi． A systematically phytochemical study Was carried out，which led to the isolation and identification of thirty·six chemical constituents including alkaloid，phenylethanoid glycosides，flavonoids and phenolics etc．Among of them，compounds 1 and 2 were determined as new compounds，compounds 3,7，20—23，37 were isolated from the genus Incarvillea(Bignoniaceae)for the first time，compounds 4-6，8-19，24-36 were isolated from this plant for the first time． In anti-inflammatory test，compounds 1，17，and 20 displayed inhibitory ability against LPS—induced NO production in RAW 264．7 macrophages． Conclusion：thirty-eight compounds were obtained from Incarvillea lutea,including 2 new compounds，7 compounds were isolated from this genus for the first time，and 28 compounds from this plant for the first time．On the basis of bioassay，it Was found that compounds 1，17，and 20 showed anti—inflammatory activity． KEY WORDS：Bignoniaceae；Incarvillea L；lncarvillea lutea；chemical constituents；alkaloids；anti-inflammatory activity -2． 黄渡罗花化学成分及其生物活性研究缩略词表 黄渡罗花化学成分及其生物活性研究 缩略词表 NMR Nuclear magnetic resonance spectroscopy lDNMR One—dimensional nuclear magnetic resonance 2DNMR Two—dimensional nuclear magnetic resonance DEPT Distortionless enhancement by polarization transfer COSY Correlation spectroscopy HMBC H··detected heteronuclear multiple—-bond correlmion NOESY Nuclear overhauser enhancement spectroscopy DMSO Dimethyl sulfoxide EI．MS Electron impact mass spectrum ESI．MS Electrospray ionization-mass spectrum HRESI—MS