氯吡格雷对急性冠状动脉综合征患者血清炎症标志物水平的影响-内科学(心血管内科)专业毕业论文.docxVIP

英文摘要EFFECT 英文摘要 EFFECT OF OOLP I DOGREL 0N NARKERS OF l NFLAMNAT 1 0N I N PAT I ENTS_I TH ACUTE CORONARY SYNDRONE Abstract Objectire To investigate the change of markers of inflammation in pat Jents with acute coronary syndrome(ACS)and the effect of Colpidogrel on markers of inflammation factors in patients with ACS．To provide medication evidence for prevention and cure ACS． Methods patients(n=68)admitted with UAP and ST—Elevation or no ST—Elevation AMI(UAP 46 cases，AMI 22 cases)were randomly divided into two groups：32 USing Clopidogrel(UAP 22 cases，AMI 10 cases)and 36 USing rout i ne theraphy group(UAP 24 cases，AMI 12 cases)．20 wi th normal contrast group．To measure blood cel ls、PT(prothrombin time)、FIB(fibringen)、 APTT(activated pactiai thrombopilastin time)、hs—CRP(High Sensitivity C-response protein)、IL～6(interleukin一6)and TNF—a(tumor necrosiS factor U)at the pretherapy and 7，14 days during fol low—up． Results ①h S—CRP、IL-6 and TNF—a in patients with ACS(17．06± 9．78mg／L、7．08±2．96pg／ml、67．09±30．78pg／m1)was significantly higher than in the normal contrast group(3．28±1．86mg／L、2．45±1．32 pg／ml、35．41±24．56 pg／m1)(PO．05)．②h S—CRP、IL-6 and TNF—a in patients with AMI(22．64± 11．62 mg／L、9．46±2．42 pg／ml、76．94±22．51 pg／m1)was significantly higher than in patients with UAP(14．78士i0．24 mg／L、5．63士3．02 Pg／m1、60．15士20．58 pg／m1)(PO．05)．③hS-CRP、IL-6 and TNF一Ⅱwas decreased in both Clopidogrel group and routine theraphy group(PO．05)．The degree of decreasing in Clopidogrel group was significantly higher than in routine theraphy group．There were no hemorrhagic tendency in both groups． Conclusion①h S—CRP、IL一6 and TNF—a in patients with ACS was significantly higher than in the normal contrast group．②hS—CRP、IL-6 and TNF—a in patients with AMl was significantly higher than in patients with UAP．⑨C]opidogrel can decreace hS-CRP、IL一6 and TNF一Ⅱin patients．prevent inflammatory reaction of coronary artery and improve prognosiS of ACS． Key words：Clopidogrel：Inflammation：Coronary disease re