柯柯豆碱生产中的催化加氢还原技术研究-制药工程专业毕业论文.docxVIP

摘 摘 要 本论文针对柯柯豆碱产品质量不稳定、成本高以及环境污染 严重等关系产品发展前景和企业效益的重大课题，通过对柯柯豆 碱生产工艺中导致上述问题的关键环节一还原工序的反应机理研 究，初步确定了催化加氢还原技术在该工序中应用的可能性，利 用大量的理论分析和实验数据，验证了该技术的应用对柯柯豆碱 产品质量、成本和环保等方面的影响，最终确定了柯柯豆碱催化 加氢还原的最佳工艺路线及参数，并首次成功地将该技术应用到 柯柯豆碱的大生产中，实现了大幅度提高产品收率、降低产品成 本、提高产品质量以及减少污染的目的。本项研究的主要内容包 括：加氢还原技术实验方案的优选、催化剂种类的筛选、催化剂 的制备与再生处理方法的确定、中间体分析方法的选择以及加氢 还原工艺涉及的催化剂用量、反应压力、反应物浓度、反应温度、 反应物流态、搅拌速度等主要参数的优化，最终通过柯柯豆碱的 大生产完成了对所选最佳工艺路线和参数的验证。 关键词： 柯柯豆碱 加氢还原技术 催化剂 AbstractThis Abstract This study iS focused on the following issues arising from the synthesis of theobromine，poor quality stability,high production cost and severe environmental pollution．The reduction，the key step leading to the development of the above．mentioned issues in meobromine synthesis．iS fully investigated，based on which the innovated unit process of reduction by addition of hydrogen iS in订oduced．In order to confirm the feasibility of applying this technique into commercial production，sufficient theoretical analysis and experimental data are provided to demonstrate the impact on the theobromine quality,production cost and environment，based on which the optimal process parameters are determined for the reduction by addition of hydrogen．The new reduction process has been put into the scale-up production with of benefits of increased yields，reduced production COst，better product quality and lower environmental pollution．The study is mainly involved in：optimization of the experimental protocol for reduction by addition of hydrogen，screening of the catalyst，preparation of catalyst and it’S regeneration，testing of in process material，and the parameters such as catalyst quantity added，reaction pressure，reaction mixture concentration and fluidity,reaction temperature and agitating speed．111e unit process route and tlle parameters are fanaliszed by the scale-up production． Key Words： Reduction by addition ofhydrogen Theobromine Catalyst 独创性声明本人声明所呈交的学位论文是本人在导师指导下进行的研究工作和取得的 独创性声明 本人声明所呈交的学位论文是本人在导师指导下进行的研究工作和取得的 研究成果，除了文中特别加以标注和致谢之处外，论文中不包含