慢性肾衰竭患者血清瘦素与胃肠肽激素变化对胃肠道症状的影响-病理学专业毕业论文.docxVIP

攫竖基堂鏊璧圭壁褰生望些搀塞 攫竖基堂鏊璧圭壁褰生望些搀塞 登蜜生鹫鳖 登蛭夔塞骛 慢性肾衰竭患者血清瘦素与胃肠肽激素变化 对胃肠道症状的影响 摘要 目的探讨慢性肾衰竭患者血渍瘦索与露肠肽激素变化对胃肠 道症状的影响。方法测定5l例慢性肾衰竭(chronic renal failure， CRF)患者(未透析8H20镑]，盘液透析组3 1例)及20例正常入(对照组)的 斑清瘦素(Leptin)、胰高m糖素(Glucagon)、胃动素(Motilin)、血清 胃泌素(Gastr／n)浓度、内生胍酹滚除率(CoO、身高、体重、及胃肠 道症状发生率等指标。分析瘦素与各参数相关性及瘦素与胃肠肽 激素变化对胃肠道症状的影响。绪果(1)血液透析组与未透析组I血 清瘦素、罚泌素、胃动索、胰赢血糖素及症状发生率明显高于对 照组，丽血液透析组与来透析组Ccr明显低予对照组’p值均小于0，01； (2)血液透析组血清瘦素、胃泌素明显高于未透析组，p值均小于 O．Ol；症状发生率低于未透析组(x≮7．18,p0。01)；(3)未透析组血清 瘦索与胃泌素呈明显负相关(F-0。786，pO．01)。结论(1)慢性肾 衰竭患者无论透析与否，血清瘦素均升高，并可能导致患者食欲降 低；(2)在未接受盘液透析的慢性肾衰竭患者中，商血清瘦素浓度对 胃泌素有明显的影响，可缝蹩等致黉肠功能紊乱的主要因素之 一e ￡羡键词l 瘦索 慢性肾衰竭 血液透析 胃肠肽激索 胃肠道症状 第2烫 整黑虽璺毽矍圭受塞生堡塑造塞 整黑虽璺毽矍圭受塞生堡塑造塞 甄塞生蕉塑 曼嘘墓鑫渣 The influence of serum leptin and gastrointestinal peptide hormones on gastrointestinal symptoms in chronic renal failure patients Objective To investigate me influence of serllm leptin and gastrointestinal peptide hormones on gastrointestinal symproms in chronic renal failure(CRF)patients．Methods Leptin，glucagon， motilin，gastrin，creatinine clearance(Ccr)，and the occurrence rate of gastrointestinal symptoms were determined in 5 1 patients with chronic renal failure(20 nondialysis and 3 1 hemodialysis)and in 20 normal human being，The correlation between the parameters and the influence Oil gastrointestinal symptoms by the variation of le·ptin and gastrointestinal peptide hormones were analysed．Results(1)In hemodialysis and nondialysis groups，leptin，gastrin，motilin， glucagon，and the occurrence rate of gastrointestinal symptoms were all significantly higher than those in normal group，but creatinine clearance WaS lower than that in normal group(Po．01)。(2)Both leptin and gastrin in hemodialysis group were significantly higher than those in nondialysis group (p0，01)；but the occurrence rate of gastrointestinal symptoms was lower than mat in nondialytic group(xk7．18，pO．01)．(3)Leptin and gastrin in nondialysis group were negalively cor