血管紧张素转换酶基因多态性与替米沙坦降压疗效关系研究.docVIP

血管紧张素转换酶基因多态性与替米沙坦降压疗效关系研 龚洪涛 杜凤和 陈步星通讯作者首都医科大学附属北京天坛医院 北京1 0 0 0 5 0 【摘要】口的探讨血管紧张素转换酶(ACE)基因的插入/缺失(I/D)多态性与 替米沙坦降压疗效Z间的关系?方法符合WHO/ISH高血压诊断标准的轻中度高 血压患者1 4 8例，服用替米沙坦单药治疗8周，在临床观察疗效的同时,应用聚 合酶链反应(PCR)对患者ACE基因I/D多态性进行分析,同时测定空腹血糖、甘油 三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇 (HDL-C)等生物化学指标?结果ACEI/D各基因型在药物治疗后每一组患者的血压 均有下降，每一组治疗前后SBP、DBP的差异均有显著统计学意义(PV0. 0 5); 而治疗前后收缩压、舒张压及降压幅度在各组Z间无明显差异(P 0?0 5).结 论ACEI/D基因多态性与替米沙坦降压疗效无相关性.【关键词】 高血压；血 管紧张素转换酶；基因多态性；血管紧张素II 1型受体拮抗剂 Association BetweenPolymorphismofAngiotensinConvertingEnzymeGeneandpressure —lowingresp on setotelmisarta ntreatme ntinH yperte nsion patients GONGHong — taoDUFeng —heCHEN Bu —xing (Departmentof Cardiology’Beijing Tiantan Hospital,CapitalUniversityof MedicalScience,Beijing 1 0 0 0 5 0 ,China)【Abstract] Objective:Toinvestigatewhethertheinsertion/deletion(l/D)polymorphismofangiote nsi n convertinge nzyme(ACE)geneareassociatedwithbloodpressureresp on setotelmisartan inhypertensivepatients. Methods:Afteratwo—weeksingle—blindplaceborun — in period, 1 4 8 patie ntswithmild —— tomoderateprimaryhypertensionreceivedmonotherapywith 8 0 mg/dayoftelmisartanandthenwerefollowedupforeightweeks. Theinsertion/deletion( l/D)polyG morphismofa ngiotensi neon vertingen zyme(ACE)ge neweredetermin edthroughPCRa na lysis. Therelati on shipbetwee nthispolymorphisma ndcha ngesi nbloodpressurewasobs ervedandevaluatedaftereightweekstreatment? Results:Thebloodpressureineachgrou pofACEI/Dge no typedecreasedaftermedicaltreat G ment. Comparedtobloodpressurebeforetreatment,systolicbloodpressure(SBP)anddi astolicbloodpressure(DBP)i neachgroupaftertreatme nthadsig nifica ntstatisticalsig nifica nce(P 0 ? 0 5 ). Andsystolicbloodpressure,diastolicpressurebeforeandaftertreatmentandpressure —lowingrangeineachgrouphavenoobviousdifference(P 0 ? 0 5 ). Conclusions:WeconcludethatACEI/Disnotassociatedwithbloodpressureresponse totelmisarta ntreatme ntin hyperte nsivepatie n【tKse ? ywords】 Esse ntialhyperte nsion; An giote nsincon vertinge nzyme; Single nu