上海交通大学耳鼻咽喉科学英文版课件 Otosclerosis.pptVIP

* Otosclerosis Otosclerosis Symptoms Slowly progressive hearing loss ipsilateral or bilateral Tinnitus in 75% Vestibular complaints 25% Histopathology lytic phase Increased osteoclastic activity results in perivascular bony resorption forming fibrotic spaces bone production phase osteoblasts within the fibrotic spaces producing immature bone remodeling phase cycling of resorption and bone formation results in otosclerotic bone Histopathology Epidemiology Hereditary in 70% of cases Autosomal dominant Incomplete penetrance 7-10% Caucasian temporal bones 1% Caucasians with symptoms Other