超氧化物歧化酶联合细胞学检查在结核性和恶性胸腹水鉴别诊断中的应用价值.docVIP

超氧化物歧化酶联合细胞学检查在结核性和恶性胸腹水鉴别诊断中的应用价值 【摘要】目的探究超氧化物歧化酶（SOD）检测联合细胞学检查在结 核性和恶性胸腹水鉴别诊断屮的应用价值。 方法利用酶联免疫吸附实验方法检测经临床确诊的200例胸腹水（其 中恶性102例，结核性98例）的SOD含量，并与细胞学检查结果进行对 比。 结果经细胞学在结核性和恶性胸腹水中的检查结果得出的敏感性为 68.6%,特异性为98.0%,准确度为83.0%； SOD法检测得出的敏感性为 66.7%,特异度为59.2%,准确度为63. 0%,这两种方法的准确度比较差异 有统计学意义（P0. 001）；最后?SOD联合细胞学检查分析得出的敏感性为 89. 2%,特异性为99. 2%,准确度为94.0%。 结论SOD检测方法可作为细胞学的重耍辅助手段，临床上应用SOD联 合细胞学方法可以提高鉴别结核性胸腹水和恶性胸腹水的准确度。 【关键词】超氧化物歧化酶；恶性胸腹水；结核性胸腹水 中图分类号：R561. 3 ； R442. 5文献标识码：ADOI : 10. 3969/j. issn. 2017. 01. 009 Application value of superoxide dismutase combined with cytology in differential diagnosis of tuberculous and malignant pleural effusion and ascites QIN Haime订，WANG Rongl, WANG Chunfangl, WEI Yeshengl, WANG Maoshui2, WANG Xinfeng2, WANG Junling2, WANG JunlilA (1. Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China； 2. Shandong Provincial Chest Hospital, Jinan 250013, China) [HJ1*2][HJ] [Abstract] ObjectiveTo explore application value of superoxide dismutase (SOD) detection combined with cytology in differential diagnosis of tuberculous and malignant pleural effusion and ascites? MethodsContent of SOD in 200 cases of confirmed pleural effusion and ascites in clinic ( included 102 malignant cases and 98 tuberculosis cases) were detected by enzymelinked immunosorbent assay (ELISA), and compared with the resuIts of cytology. ResultsSensitivity, specificity and accuracy of cytological detection in tuberculous and malignant pleural effusion and ascites was 68. 6%, 98. 0% and 830%, respectively, while the sensitivity, specificity and accuracy of SOD detection was 66.7%, 59. 2% and 63. 0%, respectively, difference of accuracy of the two methods was statistically sig ni fica nt (P 0.001) . Combi nod detection of SOD and cytology analysis showed that sensitivity, specificity and Con clusi on The detection of SOD can be used as an impor tant auxiliary cytology means, SOD combined with cytology methods can enhance accuracy in the identification