慢性前列腺炎湿热下注证与细胞因子相关性研究-中西医结合临床专业毕业论文.docxVIP

中文摘要 中文摘要 慢性前列腺炎湿热下注证与细胞因子相关性研究 慢性前列腺炎湿热下注证与细胞因子相关性研究 - - PAGE 13 - - - PAGE 10 - 中文摘要 目的：通过对慢性前列腺炎（CP）患者前列腺液中 IL-6、IL-8 值的测定，探 讨其与 CP 中医湿热下注证的相关性。 方法：选择符合慢性前列腺炎（CP）诊断标准并符合中医证型为湿热下注证 的患者 66 例，以 15 例健康志愿者作为正常对照组，测试每个研究对象前列腺液 中 IL-6 和 IL-8 的含量，通过检测结果的分析研究，得出正常人及 CP 患者 IL-6 和 IL-8 的含量特点，并评价其与 CP 患者中医湿热下注证的相关性。 结果：IL-6、IL-8 在湿热下注证与正常对照组之间比较，p0.01，两者之间 均有明显差异，具有显著统计学意义，湿热下注证明显高于正常对照组。 卵磷脂小体在湿热下注证与正常对照组之间比较， p0.01，正常对照组明显 高于湿热下注证。白细胞在湿热下注证与正常对照组之间比较， p0.01，湿热下 注证明显高于正常对照组。IL-6 与病程、年龄、NIH-CPSI 评分、卵磷脂小体无明 显相关性。IL-8 与病程、年龄、NIH-CPSI 评分无明显相关性。IL-8 与卵磷脂小体 呈显著负相关关系。白细胞与 NIH-CPSI 评分无明显相关性。IL-6、IL-8 与白细胞 三者呈正相关关系。 结论：1.CP 患者前列腺液中 IL-6、IL-8 的含量与中医湿热下注证有明显相关 性。2.前列腺液中 IL-6、 IL-8 的检测有助于慢性前列腺炎的临床诊断。3.前列 腺液中 IL-6、IL-8 有望和白细胞一样成为检测慢性前列腺炎的有效指标。4.前列 腺液中 IL-6、IL-8 和白细胞均不是评价 CP 症状严重程度的指标。 关键词：慢性前列腺炎；湿热下注； IL-6；IL-8 Relative Research into Cytokines and Types of Downward Flow of Damp-heat and Stagnancy of Qi and Blood Stasis of CP ZhangXianghui(Clinic of Integrated Traditional Chinese and Western Medicine) Directed by professor Qu Miaolin Abstract Objective:Through testing the contents of IL-6 and IL-8 in succus prostaticus of patients, to investigate its correlation with type of downward flow of damp-heat of Chinese medicine syndrome characteristics. Methods:The clinical research chose 66 patients conformed to the diagnosis standard, who are belong to the syndrome characteristics of downward flow of damp-heat type, compared with 15 healthy volunteers as normal controls. Test the contents of IL-6 and IL-8 in succus prostaticus of each object, to investigate the content specialty of IL-6 and IL-8 between normal persons and patients, and also its correlation with Chinese medicine syndrome characteristics. Result: Compared with the normal control group,downward flow of damp-heat type patients have higher IL-6 and IL-8 contents, P0.01. It shows that there are obvious differences and remarkable statistical significances between the two groups. EPS-SPL shows that the normal control group has h