麒麟加减方辨治男性不育肾精亏损证临床研究.docVIP

麒麟加减方辨治男性不育肾精亏损证临 床研究 李艳春 河南中医药大学第三附属医院 摘要: 口的:探讨麒麟加减方辨治男性不育肾精亏损证的临床疗效与安全性。方法:将 120例患者随机分为对照组和观察组。对照组采用左卡尼汀口服溶液和枸椽酸氯 米芬片治疗，连续治疗25 d,停药5 d。观察组在对照组基础上采用麒麟加减方 治疗。两组连续治疗3个月，并进行3个月随访。记录6个月内配偶妊娠情况； 治疗前后精液分析和促卵泡激素(fol 1 icle stimulating hormone, FSH)、黄 体生成素(luteinizing hormone, Lil)、睾酮(testosterone, T)、催乳素 (prolactin, PRL)和雌二醇(Estradiol, E2)等生殖激素检测,并进行治疗前 后肾虚精亏证评分及安全性评价。结果:观察组配偶妊娠23例，妊娠率38. 33%, 对照组配偶妊娠13例，妊娠率21.67%,观察组配偶妊娠率显著优于对照组 (x 2=3. 96 P0.05);治疗后观察组患者精子密度、a级精子比例、精子活率 和顶体酶活性显著优于对照组，精子畸形率显著低于对照组(P0. 05);治疗后 观察组患者FSH、LH和PRL水平显著低于(P〈0.01) , T水平显著高于对照组 (P0.01)，两组E2水平比较，差异无统计学意义(P0.05);治疗后观察组肾 精亏损证评分显著低于对照组(P〈0.01) o结论:在西医常规治疗的基础上，采 泌水平，从而提高配偶妊娠率，并能减轻肾精亏损证评分，临床使用安全。 用麒麟加减方治疗肾精亏损型男性不育,能提高患者精了质量,改善患者内分 用麒麟加减方治疗肾精亏损型男性不育, 能提高患者精了质量, 改善患者内分 关键词: 男性不育;肾精亏损证;麒麟方;牛殖激素;精子质量;中西医结合; 作者简介：李艳春(1981-)，男，河南周口人，医学硕士，主治医师，主要从 事中西医结合治疗不孕不育临床研究。 收稿日期：2017-07-20 基金：河南省中戻科技计划项目) Clinical Study on Modified Qilin Prescription for the Dialectical Treatment of Males Infert订ity with Kidney Essence Deficiency Syndrome LI Yanchun The Third Aff订iated Hospital of Herrnn University of Chinese Medicine; Abstract： Objective: To study the clinical effect and safety of modified Qilin prescription for the dialectical treatment of males infertility with kidney essenee deficiency syndrome. Methods: 120 patients were divided into control group and observation group randomly. The control group was given Levocarnitine oral solution and Clomifene Citratc tablets, and pause for 5 days after 25-day continuous treatment. The observation group was treated with modified Qilin prescription on the basis of control group. Two groups received a treatment of three months and were fol lowed up to record the gestation status of their spouses. Analyzed the sperm before and after trcatment and checked the rcproductivc hormones such as follicle stimulating hormone ( ESH) , luteinizing hormone ( LH) , testosterone ( T), prolactin ( PRL) , estradiol ( E2) , and made evaluation of kidney essence deficiency before and af